Table 2 Unadjusted and adjusted odds ratios for the association between age at CMV infection and exposure variables, stratified by ethnic group

White British

Unadjusted OR

(95% CI)

Unadjusted OR

(95% CI)

n = 379

Adjusted OR

(95% CI)

n = 379

by 12 mths

12–24 mths

uninfected at 24 mths

36 (9%)

25 (6%)

330 (84%)

Birth order (391)

1

20 (11%)

7 (4%)

157 (85%)

1.0

1.0

1.0

2

11 (9%)

12 (9%)

105 (82%)

1.21 (0.66–2.22)

1.19 (0.65–2.18)

0.81 (0.38–1.70)

3+

5 (6%)

6 (8%)

68 (86%)

0.90 (0.42–1.91)

0.80 (0.37–1.74)

0.47 (0.14–1.52)

Total household members at baseline (390)

median

IQR, range

3

2–3.5, 2–8

3

2–4, 1–6

3

2–3, 1–8

1.15 (0.91–1.46)

1.16 (0.91–1.49)

1.42 (1.01–1.99)

Duration of breastfeeding (390)

never

7 (7%)

5 (5%)

90 (88%)

1.0

1.0

1.0

<=4 weeks

7 (7%)

7 (7%)

85 (86%)

1.22 (0.53–2.78)

1.10 (0.48–2.55)

1.16 (0.47–2.82)

1–6 months

4 (4%)

5 (5%)

86 (91%)

0.77 (0.31–1.93)

0.78 (0.31–1.93)

0.89 (0.33–2.40)

6–12 months

12 (19%)

8 (12%)

45 (69%)

3.29 (1.49–7.28)

3.20 (1.45–7.10)

4.03 (1.54–10.52)

>12 months

6 (21%)

0

23 (79%)

2.18 (0.74–6.45)

2.08 (0.70–6.16)

4.05 (1.19–13.78)

Bedroom sharing in first year (389)

no

18 (8%)

14 (6%)

188 (85%)

1.0

1.0

1.0

yes

18 (11%)

11 (6%)

140 (83%)

1.23 (0.71–2.12)

1.22 (0.70–2.11)

1.67 (0.85–3.26)

Formal child care up to 12 m visit (381)

No childcare

13 (8%)

6 (4%)

142 (88%)

1.0

1.0

1.0

<1165 total hours

3 (9%)

0

31 (91%)

0.74 (0.21–2.67)

0.74 (0.21–2.65)

0.90 (0.23–3.57)

> = 1165 total hours

11 (12%)

16 (17%)

68 (71%)

2.69 (1.41–5.15)

2.71 (1.42–5.18)

3.63 (1.61–8.17)

No formal (only informal)

9 (9%)

2 (2%)

80 (88%)

1.05 (0.47–2.31)

1.04 (0.47–2.29)

1.39 (0.59–3.32)

Informal child care up to 12 m visit (376)

No childcare

13 (8%)

6 (4%)

142 (88%)

1.0

-

-

<1165 total hours

10 (8%)

5 (4%)

104 (87%)

1.08 (0.52–2.22)

> = 1165 total hours

3 (20%)

0

12 (80%)

2.05 (0.53–7.96)

No informal (only formal)

8 (9%)

14 (17%)

59 (73%)

2.52 (1.28–4.96)

Mother and baby activities in first year (389)

Rarely

22 (11%)

13 (6%)

174 (83%)

1.0

1.0

1.0

At least once a month

14 (8%)

12 (7%)

154 (86%)

0.83 (0.48–1.43)

0.87 (0.50–1.51)

0.74 (0.39–1.40)

Maternal age at recruitment (391)

Mean, SD, range

27.9, 6.1

15–38

30.1, 5.7

18–43

29.0, 6.0

16–43

0.99 (0.95–1.04)

0.99 (0.95–1.04)

0.99 (0.93–1.05)

Home ownership (391)

Yes

20 (8%)

15 (6%)

210 (86%)

1.0

1.0

1.0

No

16 (11%)

10 (7%)

120 (82%)

1.31 (0.75–2.27)

1.31 (0.75–2.28)

2.07 (0.99–4.35)

Age 24 m blood sample taken (mths) (391)

23.59–24.99

6 (7%)

3 (4%)

75 (89%)

1.0

1.0

1.0

25–26.99

23 (10%)

19 (8%)

186 (82%)

1.84 (0.86–3.96)

2.11 (0.95–4.71)

1.60 (0.68–3.77)

27–32.89

7 (9%)

3 (4%)

69 (87%)

1.22 (0.47–3.17)

1.38 (0.51–3.69)

0.95 (0.33–2.76)

Pakistani

by 12 mths

12–24 mths

uninfected at 24 mths

Unadjusted OR

(95% CI)

Unadjusted OR

(95% CI)

n = 466

Adjusted OR

(95% CI)

n = 466

162 (34%)

47 (10%)

263 (56%)

Birth order (472)

1

63 (50%)

14 (11%)

49 (39%)

1.0

1.0

1.0

2

31 (29%)

13 (12%)

63 (59%)

0.43 (0.26–0.72)

0.43 (0.26–0.71)

0.41 (0.23–0.73)

3+

68 (29%)

20 (8%)

151 (63%)

0.38 (0.25–0.58)

0.37 (0.24–0.56)

0.37 (0.22–0.64)

Total household members at baseline (472)

median

IQR, range

5

4–7, 2–12

5

4–7, 2–16

5

4–6, 2–12

1.09 (1.01–1.18)

1.09 (1.01–1.17)

1.08 (0.99–1.17)

Duration of breastfeeding (468)

never

7 (8%)

7 (8%)

70 (84%)

1.0

1.0

1.0

<=4 weeks

20 (22%)

10 (11%)

61 (67%)

2.49 (1.22–5.08)

2.53 (1.24–5.17)

2.60 (1.22–5.53)

1–6 months

45 (37%)

7 (6%)

69 (57%)

4.27 (2.18–8.36)

4.27 (2.18–8.36)

3.61 (1.79–7.27)

6–12 months

51 (50%)

12 (12%)

39 (38%)

8.34 (4.21–16.51)

8.53 (4.30–16.92)

7.38 (3.61–15.10)

>12 months

37 (53%)

11 (16%)

22 (31%)

10.03 (4.85–20.75)

10.04 (4.85–20.77)

12.57 (5.81–27.19)

Bedroom sharing in the first year (468)

no

8 (26%)

2 (6%)

21 (68%)

1.0

1.0

1.0

yes

153 (35%)

45 (10%)

239 (55%)

1.68 (0.78–3.63)

1.68 (0.78–3.62)

1.60 (0.69–3.71)

Any regular child care arrangement up to 12 m visit (468)

no

139 (34%)

39 (10%)

227 (56%)

1.0

1.0

1.0

yes

22 (35%)

8 (13%)

33 (52%)

1.10 (0.66–1.84)

1.14 (0.68–1.91)

1.23 (0.67–2.25)

Mother and baby activities in the first year (468)

Rarely

146 (36%)

40 (9%)

219 (54%)

1.0

1.0

1.0

At least once a month

15 (24%)

7 (11%)

41 (65%)

0.61 (0.35–1.05)

0.61 (0.35–1.05)

0.65 (0.35–1.19)

Travel outside Europe by 12 m visit (469)

No

134 (36%)

40 (11%)

203 (54%)

1.0

1.0

1.0

yes

27 (29%)

7 (7%)

58 (63%)

0.71 (0.45–1.12)

0.72 (0.45–1.14)

0.52 (0.31–0.87)

Maternal age at recruitment (472)

Mean, SD, range

28.2, 5.02

17–42

27.6, 4.19

19–36

29.3, 5.55

17–44

0.96 (0.93–0.99)

0.96 (0.92–0.99)

0.99 (0.94–1.03)

Mother’s country of birth (472)

UK or Ireland

47 (26%)

19 (11%)

111 (63%)

1.0

1.0

1.0

Elsewhere

115 (39%)

28 (9%)

152 (52%)

1.64 (1.13–2.38)

1.68 (1.15–2.44)

1.87 (1.20–2.92)

Home ownership (472)

Yes

94 (31%)

30 (10%)

183 (59%)

1.0

1.0

1.0

No

68 (41%)

17 (10%)

80 (49%)

1.58 (1.09–2.28)

1.56 (1.08–2.26)

1.27 (0.83–1.94)

Age 24 m blood sample taken (mths) (472)

23.59–24.99

27 (30%)

6 (7%)

58 (64%)

1.0

1.0

1.0

25–26.99

88 (37%)

29 (12%)

123 (51%)

1.56 (0.96–2.54)

1.50 (0.92–2.45)

1.22 (0.71–2.12)

27–32.89

47 (33%)

12 (9%)

82 (58%)

1.24 (0.73–2.12)

1.19 (0.70–2.04)

0.91 (0.49–1.69)