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Fig. 3 | BMC Infectious Diseases

Fig. 3

From: Brain and liver pathology, amyloid deposition, and interferon responses among older HIV-positive patients in the late HAART era

Fig. 3

Fluorescent staining of brain amyloid in HIV+ cases and controls. Representative formalin-fixed paraffin embedded autopsy brain frontal lobe tissue from HIV- (a-c) and HIV+ (d-f) cases and a known Alzheimer’s disease (AD) case (g-i) were examined by AmyloGlo staining (blue) (a-b, d-e, g-h), CD68 (green) and GFAP (red) immunofluorescence (b, e, h), or amyloid-beta (Aβ) immunohistochemistry (c, f, i). Large amyloid plaques with dense central cores were identified in one HIV+ and two HIV- cases, with peripheral GFAP-positive astrocytes and rare CD68-positive microglia. The plaques were confirmed to contain Aβ protein, and exhibited similar morphology to the positive control (AD) case. Original magnification 400×

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BMC Infectious Diseases

ISSN: 1471-2334

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