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Table 4 Multivariate analysis of cocaine/crack use and liver fibrosis progression using cut-off of 2 for APRI

From: Cocaine/crack use is not associated with fibrosis progression measured by AST-to-Platelet Ratio Index in HIV-HCV co-infected patients: a cohort study

 

Recent cocaine/crack use

 

HR

95% CI

Time independent variables (at baseline)

 Cocaine/crack use ever at baseline

0.83

0.50, 1.40

 Baseline age (per 10 years)

1.04

0.83, 1.29

 Female sex

1.48

1.03, 2.13

 Baseline HCV infection duration (per 5 years)

1.05

0.95, 1.16

 Baseline ln (APRI)

2.54

1.69, 3.81

Time updated variables

 Recent cocaine/crack use

0.69

0.45, 1.04

 Recent other drug usea

1.19

0.82, 1.72

 Current alcohol abuseb

1.76

1.14, 2.72

 CD4 count (per 100 cells/μL)

0.91

0.85, 0.98

  1. aHeroin and opiates, steroids, methylphenidate, hallucinogens (PCP, LSD), benzodiazepine, barbiturates, methamphetamine, amphetamine, other
  2. bDefined as >6 drinks at least once a month and >2 drinks on a typical day when drinking