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Table 2 Clinical characteristics of RSV-positive infants, categorised by disease severity

From: Thymus activity measured by T-cell receptor excision circles in patients with different severities of respiratory syncytial virus infection

 

Mild

Moderate

Severe

Sig.

Total number of patients

37

 

25

 

40

  

 TREC during RSV infection, number of patients

13

 

10

 

24

  

 TREC in neonatal screening cards, number of patients

32

 

24

 

29

  

Age when RSV diseased - months, median (IQR)

3

(1–6)

3

(1–5.5)

2

(1–4)

p = 0.4a

Male gender, number (%)

14

(38%)

14

(56%)

17

(43%)

p = 0.4b

Weight - grams, mean (SD)

6522

(2277)

6748

(1935)

5974

(2065)

p = 0.4c

Duration of symptoms at admission - days, median (IQR)

4

(3–5.25)

4

(3.5–5)

4

(3–5)

p = 0.9a

Admission, number (%)

20

(54%)

25

(100%)

40

(100%)

 

Length of stay, median (IQR)

1

(0–1)

1

(1–3)

4

(2.5–5.5)

p < 0.0001d

Length of stay > 3 days, number (%)

1

(3%)

3

(12%)

24

(62%)

p < 0.0001e

Respiratory distress

 SpO2 - % on admission, mean (SD)

97.4

(2.6)

97.9

(2.3)

94.7

(4.5)

p < 0.0001c

 Respiratory rate /min on admission, mean (SD)

49

(12)

58

(12)

57

(10)

p = 0.002c

 Respiratory rate score (max. 8), median (IQR)

2

(0.75–4.25)

4

(2.5–6)

4

(2–6)

p = 0.007a

       

p = 0.4d

 Retraction score (max. 9), median (IQR)

1

(0–2)

4

(2.25–6)

2

(1–4)

p < 0.0001a

       

p = 0.003d

 Wheeze score (max. 8), median (IQR)

0

(0–3)

5

(4–6)

2

(0–4)

p < 0.0001a

       

p = 0.0002d

 m-RDAI, median (IQR)

6

(2–8)

13

(10.5–16)

8

(6–11)

p < 0.0001a

       

p < 0.0001d

Treatments

 Fluid supplement, number (%)

    

16

(40%)

 

  Intravenous fluids, number (%)

    

4

(10%)

 

  Nasogastric fluid, number (%)

    

14

(35%)

 

 Oxygen supplement, number (%)

    

35

(88%)

 

 CPAP, number (%)

    

4

(10%)

 

 Respirator, number (%)

    

0

(0%)

 
  1. Of 113 patients available for the study, 92 were included. Fourtyseven had TREC analysed during acute RSV infection, 85 had TREC analysed in neonatal screening cards. Values presented and statistical tests are performed using the total number of RSV positive children included in this study. Analyses show similar results when including only infants studied in the analysis of TREC during RSV infection, or only infants studied in the analysis of neonatal TREC (details not presented). There were no significant differences in age, weight, gender or duration of symptoms between disease severity groups. The severe disease group had a lower SpO2 on admission, but had less respiratory distress than the moderate group, as measured by the m-RDAI. The retraction and wheeze scores in particular contributed to this difference. Length of hospital stay increased with increasing severity. The most common treatment for children with severe disease was oxygen supplementation. Only four children required admission to intensive care for CPAP. None were ventilated
  2. aKruskal-Wallis test
  3. bChi-Square test
  4. cOne-way ANOVA
  5. dMann-Whitney test, comparing moderate and severe disease subgroups
  6. eFisher’s exact test, comparing moderate and severe disease subgroups