Table 1 Clinical characteristics of neonates with and without candidemia
Variable | Case mean (95% CI) or n(%) | Control mean (95% CI) or n(%) | P value | Odds ratio (OR) (95% CI) |
|---|---|---|---|---|
Demographics | ||||
Gestational age (wks) | 31.7(28.2, 35.2) | 31.6(27.8, 35.4) | 0.763 | |
Birth weight (g) | 1514.4(852.0,2176.3) | 1529.3(856.5,2202.1) | 0.894 | |
Male gender, n(%) | 44(63.8) | 41(59.4) | 0.600 | 1.20(0.61–2.39) |
Admission age | 1.1(0.8, 1.4) | 1.5(1.2, 4.2) | 0.149 | |
Risk factors | ||||
Vaginal delivery | 28(40.6) | 33(47.8) | 0.392 | 0.75(0.38–1.46) |
Necrotizing enterocolitis | 16(23.2) | 6(8.7) | 0.025 | 3.17(1.16–8.68) |
Neurodevelopmental impairment | 14(20.3) | 2(2.9) | 0.006 | 8.52(1.86–39.14) |
Maternal underlying diseases | 31(44.9) | 19(27.5) | 0.035 | 2.15(1.06–4.37) |
Abdominal surgery | 10(14.5) | 3(4.4) | 0.057 | 3.67(0.96–13.99) |
Mechanical ventilation | 43(62.3) | 28(40.6) | 0.011 | 2.42(1.22–4.80) |
Central venous catheter | 40(58.0) | 24(34.8) | 0.007 | 2.59(1.30–5.15) |
Intubation | 31(44.9) | 17(24.6) | 0.013 | 2.50(1.21–5.15) |
Rescue history | 35(50.7) | 26(37.7) | 0.124 | 1.70(0.86–3.35) |
Total parenteral nutrition | 58(84.1) | 23(33.3) | 0.000 | 10.55(4.66–23.85) |
Hospitalization duration (d) | 46.6(23.3, 69.9) | 24.5(5.7, 43.3) | 0.000 | |
3rd cephalosporins use | 39(57.4) | 29(42.0) | 0.074 | 1.86(0.94–3.65) |
Carbapenems use | 50(72.5) | 15(21.7) | 0.000 | 9.47(4.35–20.64) |
Vancomycin use | 10(14.5) | 5(7.2) | 0.179 | 12.17(0.70–6.72) |
Multiple antibiotic use | 37(53.6) | 9(13.0) | 0.000 | 7.71(3.31–17.95) |
Antibiotic therapeutic duration (d) | 33.5(14.7, 52.3) | 13.8(2.5, 25.1) | 0.000 | |
Outcome | ||||
Cure | 16(23.2) | 32(46.4) | reference | reference |
Improvement | 43(62.3) | 33(47.8) | 0.013 | 2.61(1.23–5.53) |
Exacerbation | 5(7.2) | 3(4.3) | 0.128 | 3.33(0.71–15.74) |
Death | 5(7.2) | 1(1.4) | 0.043 | 10.00(1.08–92.94) |