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Fig. 5 | BMC Infectious Diseases

Fig. 5

From: A new tool for tuberculosis vaccine screening: Ex vivo Mycobacterial Growth Inhibition Assay indicates BCG-mediated protection in a murine model of tuberculosis

Fig. 5

Ex vivo MGIA reflects importance of IFNγ for growth control of mycobacteria. 1 × 106, 2 × 106, and 3 × 106 splenocytes from IFNγ-deficient (filled diamonds) or wild type mice (grey triangles) were co-cultured with 750 CFU (a) or 100 CFU (b) of BCG Pasteur Aeras. Splenocytes were obtained from a total of 5 IFNγ-deficient and 5 wild type animals. Aliquots from each spleen were cultured with different numbers of mycobacteria as indicated, and are represented by individual data points. Error bars represent the median +/- interquartile range. Statistical significance was tested using the unpaired t test function in GraphPad Prism

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BMC Infectious Diseases

ISSN: 1471-2334

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