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Table 4 Diagnostic value of initial symptoms in patients admitted to the Moyamba Ebola Treatment Center

From: Clinical features of suspected Ebola cases referred to the Moyamba ETC, Sierra Leone: challenges in the later stages of the 2014 outbreak

 

Sensitivity (95 % CI)

Specificity (95 % CI)

Likelihood ratio positive (95 % CI)

Likelihood ratio negative (95 % CI)

PPV (95 % CI)

NPV (95 % CI)

Contact

100 (*)

59 (43.5–74.4)

2.4 (1.7–3.6)

*

59 (43.5–74.4)

100 (*)

Fever (≥38 °C or referred)

61.3 (44.1–78.4)

29.5 (16.1–43)

0.9 (0.6–1.2)

1.3 (0.7–2.5)

38 (24.5–51.5)

52 (32.4–71.6)

Vomiting

58.1 (40.7–75.4)

70.5 (57–83.9)

2 (1.1–3.4)

0.6 (0.4–1.0)

58.1 (40.7–75.4)

70.5 (57–83.9)

Diarrhea

67.7 (51.3–84.2)

70.5 (57–83.9)

2.3 (1.4–3.8)

0.5 (0.3–0.8)

61.8 (45.4–78.1)

75.6 (62.5–88.8)

Fatigue

96.8 (90.6–100)

43.2 (28.5–57.8)

1.7 (1.3–2.2)

0.1 (0–0.5)

54.5 (41.4–67.7)

95 (85.4–100)

Anorexia

61.3 (44.1–78.4)

61.4 (47–75.8)

1.6 (1–2.5)

0.6 (0.4–1)

52.8 (36.5–69.1)

69.2 (54.7–83.7)

Abdominal pain

45.2 (27.6–62.7)

54.5 (39.8–69.3)

1 (0.6–1.6)

1 (0.7–1.6)

41.2 (24.6–57.7)

58.5 (43.5–73.6)

Chest pain

22.6 (7.9–37.3)

79.5 (67.6–91.5)

1.1 (0.5–2.6)

1.0 (0.8–1.2)

43.8 (19.4–68.1)

59.3 (46.8–61.9)

Muscle pain

61.3 (44.1–78.4)

70.5 (57–83.9)

2.1 (1.2–3.5)

0.5 (0.3–0.9)

59.4 (42.4–76.4)

72.1 (58.7–85.5)

Joint pain

51.6 (34–69.2)

61.4 (47–75.8)

1.3 (0.8–2.2)

0.8 (0.5–1.2)

48.5 (31.4–65.5)

64.3 (49.8–78.8)

Headache

54.8 (37.3–72.4)

61.4 (47–75.8)

1.4 (0.9–2.3)

0.7 (0.5–1.2)

50 (33.2–66.8)

65.9 (51.3–80.4)

Back pain

6.5 (0–15.1)

93.2 (85.7–100)

0.9 (0.2–5.3)

1.0 (0.9–1.1)

40.0 (−2.9–82.9)

58.6 (47.0–70.1)

Dysphagia

25.8 (10.4–41.2)

100 (*)

*

0.7 (0.6–0.9)

100 (*)

65.7 (54.3–77)

Red eyes

38.7 (21.6–55.9)

81.8 (70.4–93.2)

2.1 (1–4.6)

0.7 (0.5–1)

60 (38.5–81.5)

65.5 (47.6–70.2)

Skin rash

3.2 (0–9.4)

97.7 (93.3–100)

1.4 (0.1–21.8)

1.0 (0.9–1.1)

50.0 (0–100)

58.9 (47.6–70.2)

Hiccups

6.5 (0–15.1)

86.4 (76.2–96.5)

0.5 (0.1–2.2)

1.1 (1.0–1.3)

25 (0–55)

56.7 (44.9–68.6)

Confused / disoriented

3.2 (0–9.4)

90.9 (82.4–99.4)

0.3 (0–3)

1.1 (1.0–1.2)

20.0 (0–55.1)

57.1 (45.5–68.7)

Bleeding

35.5 (18.6–52.3)

100 (*)

*

0.6 (0.5–0.8)

100.0 (*)

68.8 (57.4–80.1)

Fatigue/anorexia

96.8 (90.6–100)

38.6 (24.2–53.0)

1.10 (0.79–1.55)

0.83 (0.44–1.57)

43.8 (29.7–57.8)

63.0 (44.7–81.2)

Digestive symptoms

83.9 (70.9–96.8)

45.5 (30.7–60.2)

1.54 (1.13–2.10)

0.35 (0.15–0.84)

52.0 (38.2–65.8)

80.0 (64.3–95.7)

Musculoskeletal pain

67.7 (51.3–84.2)

38.6 (24.2–53.0)

1.10 (0.79–1.55)

0.83 (0.44–1.57)

43.8 (29.7–57.8)

63.0 (44.7–81.2)

Headache / Pain behind eyes

54.8 (37.3–72.4)

61.4 (47.0–75.8)

1.42 (0.87–2.32)

0.74 (0.47–1.16)

50.0 (33.2–66.8)

65.9 (51.3–80.4)

Neurological symptoms

3.2 (0–9.4)

90.9 (82.4–99.4)

0.35 (0.04–3.02)

1.06 (0.95–1.19)

20.0 (0–55.1)

57.1 (45.5–68.7)

Contact + Fever

48.4 (30.8–66)

77.3 (64.9–89.7)

2.1 (1.1–4.1)

0.7 (0.5–1)

60 (40.8–79.2)

68.0 (55.1–80.9)

Contact + 3 symptoms

67.7 (51.3–84.2)

81.8 (70.4–93.2)

3.7 (1.9–7.3)

0.4 (0.2–0.7)

72.4 (56.1–88.7)

78.3 (66.3–90.2)

Fever + 3 symptoms

58.1 (40.7–75.4)

50 (35.2–64.8)

1.2 (0.8–1.8)

0.8 (0.5–1.4)

45 (29.6–60.4)

62.9 (46.8–78.9)

Any WHO criterion

87.1 (75.3–98.9)

40.9 (26.4–55.4)

1.5 (1.1–1.9)

0.3 (0.1–0.8)

50.9 (37.5–64.4)

81.8 (65.7–97.9)

  1. NPV negative predictive value, PPV positive predictive value
  2. * = 95%CI not applicable