Fig. 2

Longitudinal serum analysis of patients with reversal reaction (RR) Levels of IP-10 a and CCL18 b in unstimulated sera derived from 10 leprosy patients (left panels) developing RR (Bangladesh: n = 4; Brazil; n = 3; Ethiopia: n = 1; Nepal: n = 2) in the absence of any clinical signs of reactions and at least three months before reaction (before RR), at diagnosis of reaction before steroids (RR) or after MDT and RR, at least one month after end of steroids (after RR), or from healthy Dutch controls (n = 10) at two sequential time points with six months intervals (right panels). For calculations of the ROC values, time points at least three months before RR and at RR diagnosis before steroids were considered. IFN-β levels for controls were not detectable