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Table 3 Factors associated with the incidence of the first malaria event (n = 48) in the 1117 HIV-infected children included in the pWADA cohort. Abidjan May-August 2012

From: Effect of cotrimoxazole prophylaxis on the incidence of malaria in HIV-infected children in 2012, in Abidjan, Côte d’Ivoire: a prospective cohort study

 

N

n

Univariate analysis

Adjusted analysis

IRR

(95 % IC)

p-value

aIRR

(95 % CI)

p-value

Antiretroviral therapy (ART) and cotrimoxazole exposure

    

<0.01

  

<0.01

On ART - On cotrimoxazole

667

7

0.07

(0.02-0.21)

<0.01

0.05

(0.02-0.18)

<0.01

Off ART - On cotrimoxazole

83

2

0.16

(0.03-0.80)

0.03

0.13

(0.02-0.69)

0.02

On ART - Off cotrimoxazole

332

34

0.69

(0.27-1.77)

0.44

0.69

(0.27-1.77)

0.44

Off ART - Off cotrimoxazole

35

5

1

-

-

1

-

-

Immunodeficiency for Age a

    

0.38

  

0.02

Severe

69

5

1.87

(0.73-4.76)

0.19

4.03

(1.55-10.47)

<0.01

Moderate

106

6

1.44

(0.61-3.40)

0.41

2.14

(0.89-5.14)

0.09

No/Missing

942

40

1

-

-

1

-

-

Age

    

0.14

   

<5 years

144

11

2.18

(1.04-4.58)

0.04

 

Not included

 

[5-10[years

443

18

1.13

(0.59-2.16)

0.70

   

≥10 years

530

19

1

-

-

   

Centres

    

<0.01

   

CHU de Cocody

182

1

1

-

-

   

CHU de Yopougon

344

9

4.80

(0.61-37.87)

0.14

 

Not included

 

CePReF

322

20

11.66

(1.56-86.91)

0.02

   

CIRBA

212

7

6.11

(0.75-49.65)

0.09

   

MTCT-Plus

57

11

38.72

(5.00-299.97)

<0.01

   
  1. N: number of children; n: number of malaria incident cases (confirmed and probable); IRR: incidence rate ratio; aIRR, adjusted incidence rate ratio; 95 % CI:95 % Confidence Interval. aUsing the 2010 WHO definition