Table 1 Double exponential model PK parameters for 50Â kg adult patient
| Â | AM | LF | DHA | PPQ | PQ |
|---|---|---|---|---|---|
Adult dose | 80Â mg | 480Â mg | 120Â mg | 960Â mg | 15Â mg |
Cmax (μg/L) | 114 | 1017 | 200 | 30 | 75 |
Cmax scaling factor | 0.5 | 1.5 | 0.25 | 0.5 | 1 |
Decay constant A (1/day) | 0.12 | 1.3 | 0.12 | 0.17 | 0.36 |
Decay constant B (1/day) | -- | 2.0 | -- | 41 | -- |
V | -- | 1.2 | -- | 49 | -- |