Figure 4

Correlation between MMP-9 levels and intracranial complications in mice with MM. Brain samples from control and treated animals were subjected to different assays as described in Figures 2 and 3. A-C. Control mice (open squares). D-F. Pooled data of control (open squares) and BB-94-treated animals (closed squares). The amount of MMP-9 assessed by zymography was associated with the number of bleeding spots (A, D), the size of haemorrhages (B, E), and the disruption of BBB (C, F). Correlation analysis was performed by the Pearson’s test (p < 0.05).