Table 1 Biochemical, histologic, virologic and serologic changes in response to experimental inoculation of nude mice with HEV
From: Experimental infection of Balb/c nude mice with Hepatitis E virus
Group | Â | No.1 | No.2 | No.3 |
|---|---|---|---|---|
HEV-RNA (feces) | 0d | - | - | - |
| Â | 4d | - | +(4/4) | - |
| Â | 7d | - | +(4/4) | +(1/4) |
| Â | 14d | - | +(4/4) | +(1/4) |
| Â | 21d | - | - | - |
| Â | Liver | - | +(4/4) | +(1/4) |
| Â | Spleen | - | +(4/4) | +(1/4) |
| Â | Kidney | - | +(4/4) | +(1/4) |
HEV-antigen | Jejunum | - | +(4/4) | - |
| Â | Ileum | - | +(4/4) | - |
| Â | Colon | - | +(4/4) | - |
Anti-HEV IgG | Â | - | +(4/4) | +(1/4) |
IHC | Â | - | +(4/4) | +(1/4) |
ALT | Â | --- | --- | --- |
AST |  | --- | ↑ | ↑ |
ALP |  | --- | ↑ | ↑ |
TBIL | Â | --- | --- | --- |
Histologic change | Â | no change | obvious | obvious |