From: Diagnosing norovirus-associated infectious intestinal disease using viral load
Reference groups used | Optimal Ct cut-off | Youden Index | Sensitivity (95% CI) | Specificity (95% CI) | AUC | Sample size | |
---|---|---|---|---|---|---|---|
 |  |  |  |  |  | Reference positive | Reference negative |
Ref positive 1 Ref negative 1 | Â | Â | Â | Â | Â | Â | Â |
All | 31 | 0.77 | 0.88 (0.65–1.00) | 0.89 (0.84–0.94) | 0.93 | 92 | 159 |
aged <5 years | 30 | 0.80 | 0.94 (0.84–1.00) | 0.86 (0.79–0.93) | 0.93 | 48 | 92 |
aged >5 years | 33 | 0.83 | 0.89 (0.79–0.98) | 0.94 (0.88–1.00) | 0.96 | 44 | 67 |
Ref positive 2 | Â | Â | Â | Â | Â | Â | Â |
Ref negative 1 | Â | Â | Â | Â | Â | Â | Â |
 | 31 | 0.61 | 0.72 (0.66–0.79) | 0.89 (0.84–0.94) | 0.87 | 169 | 159 |
Ref positive 3 | Â | Â | Â | Â | Â | Â | Â |
Ref negative 2 | Â | Â | Â | Â | Â | Â | Â |
 | 31 | 0.29 | 0.43 (0.39–0.47) | 0.86 (0.77–0.94) | 0.64 | 524 | 64 |