From: Diagnosing norovirus-associated infectious intestinal disease using viral load
Reference group | Inclusion Criteria |
---|---|
Reference positive 1 | 1. IID 2. Norovirus detected by electron microscopy 3. Norovirus infection confirmed by RT-PCR |
Reference positive 2 | 1. IID 2. Norovirus detected by electron microscopy 3. Norovirus infection confirmed by RT-PCR Or 1. IID 2. Electron microscopy negative 3. Norovirus detected by RT-PCR 4. No other pathogen detected 5. Specimen collected within 3 days of symptom onset |
Reference positive 3 | 1. IID 2. Norovirus detected by electron microscopy and/or RT-PCR 3. Negative for Campylobacter spp., Salmonella spp. and Shigella spp. by bacterial culture and Cryptosporidiumspp. by light microscopy (and rotavirus A by ELISA in children aged less than five years only) |
Reference negative 1 | 1. No history of IID in previous 3 weeks 2. Norovirus detected by RT-PCR |
Reference negative 2 | 1. IID 2. Norovirus detected by RT-PCR 3. Infection with Salmonella spp., Campylobacter spp. or Shigella spp. detected by bacterial culture or Cryptosporidium spp. detected by light microscopy (or rotavirus A by ELISA in children aged less than five years only) |