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Table 3 Risk factors associated with overall survival

From: Risk and prognostic significance of tuberculosis in patients from The TREAT Asia HIV Observational Database

     

Univariate

Multivariate

 

No. of patients

Follow up (years)

No. of events

Rate

HR

p

HR (95% CI)

p-value

Total

3279

6968

142

2.04

    

Sex

Male

2307

4992

105

2.10

    

Female

972

1976

37

1.87

0.89

0.527

1.07 (0.73, 1.57)

0.732

Age at entry of TAHOD (years)

< = 30

1103

2270

40

1.76

    

31~40

1401

3016

50

1.66

0.95

0.812

0.86 (0.57, 1.32)

0.497

41+

775

1682

52

3.09

1.78

0.006

1.79 (1.18, 2.71)

0.006

Reported mode of infection

Heterosexual contact

2288

5013

97

1.94

    

Homosexual contact

614

1261

12

0.95

0.47

0.014

0.68 (0.21, 1.25)

0.368

Injecting drug use

132

276

14

5.08

2.54

0.001

1.40 (0.27, 2.53)

0.772

Blood products

120

196

7

3.58

1.77

0.144

1.57 (0.26, 3.44)

0.721

Other/unknown

125

222

12

5.40

2.65

0.001

1.63 (0.12, 3.01)

0.883

CD4 count (cells/μL) *

< = 50

316

268

51

19.02

    

51–100

325

246

16

6.49

0.35

<0.001

0.37 (0.21, 0.66)

0.001

101–200

939

875

20

2.29

0.12

<0.001

0.14 (0.08, 0.24)

<0.001

201–300

1238

1276

19

1.49

0.08

<0.001

0.10 (0.06, 0.17)

<0.001

301+

2242

4244

22

0.52

0.03

<0.001

0.04 (0.02, 0.07)

<0.001

Not tested

68

59

14

23.68

1.18

0.592

0.86 (0.46, 1.58)

0.622

Country of TB burden

High

1990

3775

95

2.52

    

Low/intermediate

1289

3193

47

1.47

0.62

0.007

0.86 (0.60, 1.26)

0.435

Antiretroviral treatment *

No treatment

830

1006

44

4.37

    

Treated, 0~90 days

475

88

8

9.14

1.89

0.103

1.08 (0.50, 2.35)

0.846

Treated, 91–180 days

703

154

5

3.24

0.67

0.405

0.39 (0.15, 0.99)

0.049

Treated, 181–360 days

1048

428

21

4.91

1.06

0.838

0.73 (0.42, 1.27)

0.265

Treated 361+ days

2478

5292

64

1.21

0.31

<0.001

0.32 (0.21, 0.51)

<0.001

Disease stage *

CDC Category A

1444

2900

37

1.28

    

CDC Category B

442

824

12

1.46

1.15

0.679

0.95 (0.49, 1.84)

0.886

TB only

328

634

13

2.05

1.65

0.122

1.53 (0.80, 2.91)

0.197

TB + CDC Category B

202

382

8

2.09

1.70

0.175

0.99 (0.45, 2.16)

0.976

Single non-TB ADI

523

1035

22

2.13

1.69

0.051

1.40 (0.80, 2.42)

0.237

Multiple non-TB ADIs

212

461

19

4.12

3.34

<0.001

2.27 (1.25, 4.10)

0.007

TB and other ADI(s)

336

732

31

4.23

3.57

<0.001

2.12 (1.27, 3.55)

0.004

  1. Rate: per 100 person years. HR: hazard ratio. CI: confidence interval. ADI: AIDS defining illness.
  2. * Time dependent variable, patients can contribute person time to more than one category thus the sum of the categories may be more than the total number of patients.
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BMC Infectious Diseases

ISSN: 1471-2334

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