From: Low sensitivity of a urine LAM-ELISA in the diagnosis of pulmonary tuberculosis
 |  | Sensitivity % (95% CI) | Specificity % (95% CI) | Positive predictive value % (95% CI) | Negative predictive value % (95% CI) | Positive diagnostic likelihood ratio (95% CI) | Negative diagnostic likelihood ratio (95% CI) |
---|---|---|---|---|---|---|---|
 | Subgroup (n) |  |  |  |  |  |  |
LAM positivity in at least one out of two urine samples in combination with | Â | Â | Â | Â | Â | Â | Â |
Lymphadenopathy | All (149) | 7.4 (2.4–16.3) | 98.8 (93.3–100.0) | 83.3 (35.9–99.6) | 55.9 (47.4–64.2) | 5.96 (0.71–49.80) | 0.94 (0.87–1.01) |
Body temperature ≥ 37.5°C | All (149) | 23.9 (14.3–35.9) | 98.8 (93.4–100.0) | 94.1 (71.3–99.9) | 61.4 (52.5–69.7) | 19.60 (2.67–144.0) | 0.77 (0.67–0.88) |
Fever* | All (150) | 44.9 (32.9–57.4) | 91.4 (83.0–96.5) | 81.6 (65.7–92.3) | 66.1 (56.5–74.7) | 5.20 (2.44–11.10) | 0.60 (0.48–0.75) |
Body weakness* | All (151) | 49.3 (37.0–61.6) | 89.0 (80.2–94.9) | 79.1 (64.0–90.0) | 67.6 (57.9–76.3) | 4.49 (2.32–8.70) | 0.57 (0.45–0.73) |
Chest pain* | All (151) | 50.7 (38.4–63.0) | 87.8 (78.7–94.0) | 77.8 (62.9–88.8) | 67.9 (58.2–76.7) | 4.16 (2.23–7.78) | 0.56 (0.44–0.72) |
Cough* | All (151) | 50.7 (38.4–63.0) | 87.8 (78.7–94.0) | 77.8 (62.9–88.8) | 67.9 (58.2–76.7) | 4.16 (2.23–7.78) | 0.56 (0.44–0.72) |
Expectoration* | All (151) | 47.8 (35.6–60.2) | 87.8 (78.7–94.0) | 76.7 (61.4–88.2) | 66.7 (56.9–75.4) | 3.92 (2.09–7.37) | 0.59 (0.47–0.76) |
Haemoptysis* | All (151) | 2.9 (0.4–10.1) | 98.8 (93.4–100.0) | 66.7 (9.4–99.2) | 54.7 (46.3–62.9) | 2.38 (0.22–25.70) | 0.98 (0.94–1.03) |
Loss of Appetite* | All (151) | 30.4 (19.9–42.7) | 95.1 (88.0–98.7) | 84.0 (63.9–95.5) | 61.9 (52.8–70.4) | 6.24 (2.25–17.30) | 0.73 (0.62–0.86) |
Night sweat* | All (151) | 46.4 (34.3–58.8) | 92.7 (84.8–97.3) | 84.2 (68.7–94.0) | 67.3 (57.8–75.8) | 6.34 (2.82–14.30) | 0.58 (0.46–0.73) |