Mean (SD) or number (%) | Primary sepsis n = 117 | Secondary sepsis n = 62 | p |
---|---|---|---|
Time elapsed from ICU admission (N. of days) | 2.0 (2.4) | 15.6 (16.9) | < 0.0001 |
SOFA score | 6.9 (4.1) | 7.2 (3.9) | 0.706 |
Platelet count (cell/mm3) | 185,459 (118,375) | 235,935 (183,485) | 0.028 |
Creatininemia (μmol/L) | 198.7 (168.5) | 163.2 (129.2) | 0.149 |
Prothrombin time (%) | 58.8 (21.9) | 62.8 (19.9) | 0.248 |
Septic shock | 60 (51.7) | 31 (50.0) | 0.302 |
Nosocomial sepsis ICU acquired sepsis | 34 (35.8) 31 (26.5) | 62 (100) 52 (83.9) | < 0.0001 < 0.0001 |
Infection source | 0.002 | ||
Lung | 30 (25.6) | 12 (19.3) | 0.447 |
Abdominal | 23 (19.7) | 18 (29.0) | 0.217 |
Soft tissues | 13 (11.1) | 4 (6.4) | 0.456 |
Urinary tract | 24 (20.5) | 2 (3.2) | 0.004 |
Miscellaneous | 9 (7.7) | 5 (8.1) | 0.480 |
Unknown | 18 (15.4) | 21 (33.9) | 0.008 |
Involved pathogen bacteria | 113 (95.6) | 41 (64.4) | < 0.0001 |
Gram positive | 51 (43.6) | 20 (32.2) | |
Gram negative | 62 (53.0) | 21 (33.9) | |
fungi | |||
Candida spp | 4 (3.4) | 21 (33.9) | |
Previous exposure to antibiotic therapy with in vitro activity against the involved pathogen | 16 (13.7) | 21 (33.9) | 0.003 |
Previous exposure to steroids | 9 (7.7) | 23 (37.1) | < 0.0001 |
Time elapsed between bacteremia onset and PCT sampling (N. of minutes) | |||
Mean (SD) | -169.7 (382.6) | 6.3 (455.4) | 0.011 |
Median [range] | -13.0 [-1072–720] | 0.0 [-720–720] |