Figure 2

A) Bacterial numbers in brain 12, 24 and 48 h after infection with 3 × 10³ CFU of S. pneumoniae in wt (n = 18), TLR2^-/- (n = 18), CD14^-/- (n = 17) and TLR2^-/-/CD14^-/- (n = 6) mice. Median values and 25–75% spread (p < 0.02, ANOVA). B) TNF levels in CSF in wt (n = 21), TLR2^-/- (n = 13), CD14^-/- (n = 14) and TLR2^-/-/CD14^-/- (n = 6) mice 12 and 24 h after infection. Mean values ± SD (p < 0.02, ANOVA). C) Leukocyte numbers in CSF in wt (n = 15), TLR2^-/- (n = 10), CD14^-/- (n = 14) and TLR2^-/-/CD14^-/- (n = 6) mice 12 to 48 h after infection. Median values (p < 0.02, ANOVA).