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Table 3 Evaluation of synergy: time killing curves on 5 MRSA strains

From: In vitro evaluation of antibiotics' combinations for empirical therapy of suspected methicillin resistant Staphylococcus aureussevere respiratory infections

Combination

Nr of strains showing synergy/indifference at:

 

2 h

6 h

12 h

24 h

LVX + VA

0/5

0/5

2/3

5

LVX + TEC

0/5

0/5

3/2

5/0

CTX + VA

0/5

1/4

5/0

5/0

CTX + TEC

0/5

0/5

5/0

5/0

LVX + VA + AMK

0/5

0/5

0/5

3/2

LVX + TEC + AMK

0/5

0/5

0/5

4/1

LVX + VA + CAZ

0/5

0/5

0/5

2/3

LVX + TEC + CAZ

0/5

1/4

2/3

3/2

LVX + VA + FEP

0/5

0/5

0/5

3/2

LVX + TEC + FEP

0/5

0/5

1/4

3/2

LVX + VA + IPM

0/5

0/5

1/4

3/2

LVX + TEC + IPM

0/5

1/4

2/3

3/2

LVX + VA + TZP

0/5

0/5

2/3

2/3

LVX + TEC + TZP

0/5

0/5

3/2

3/2

  1. LVX: levofloxacin; VA: vancomycin; TEC: teicoplanin; CTX: cefotaxime; AMK: amikacin; CAZ: ceftazidime; FEP: cefepime; IPM: imipenem; TZP: piperacillin/tazobactam.