Figure 4
Pharmacokinetic levels of daptomycin in rat tissue cage fluids on day 4 of therapy with twice-daily (closed symbols) or once-daily (open symbols) doses of daptomycin (30 mg/kg). The tissue cage fluid AUC0-24hof rats treated with twice-daily and once-daily regimens of daptomycin were 1073 and 196 mg × h/L, respectively. The values for each time point are the mean (+ SEM) daptomycin TCF levels determined in six different animals.