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Table 1 Studies reporting patients with fungal neutropenic enterocolitis

From: Invasive fungal infections in neutropenic enterocolitis: A systematic analysis of pathogens, incidence, treatment and mortality in adult patients

Study

Study type

No. pts. with fungal NE

Disease

OP?

Outcome

Spec.

Pathogen

Additional study details

[45]

CR

1

AML

OP

survived

Histology

Candida spp. + grampositive cocci

CR providing sufficient details

[46]

CS2C

1

ALL

OP

survived

Blood culture+ histology

Candida spp.

CR providing sufficient details, 1 case of IFI among 2 cases of NE

[47]

PCS

1

HMNS

n.s.

dead

Blood culture

Candida spp.

Early detailled autopsy series (69 pts), 1 confirmed fungaemia, 3 questionable cases of IFI

[48]

MCS

4 (or more)

AML

n.s.

n.s.

Blood culture

Candida spp.

Acurate retrospective study of D-Xylose malabsorption in110 AML patients. Malabsorption was associated with candidemia but no. of patients with this combination was not completely clear

[22]

CR

1

AML

NOP

survived

Blood culture

Candida albicans + P.aeruginosa.

CR providing sufficient details

[19]

MCS

5

AL

n.s.

dead

Histology

Candida albicans 3 pts Candida glabrata 1 pt Aspergillus fumigatus 1 pt

Large retrospective study. Important description of bowel wall thickening as negative prognostic factor in 88 pat. with NE. Limitation: Blood culture results are not reported.

[49]

CS3C

1

HMNS

OP

survived

Blood culture

Fungus n.s.

CS of 3 pat. with NE (1*fungaemia) among 18 pat. with abdominal complications. Few patient details. Pat. were not consecutive.

[50]

CS2C

1

AML

OP

survived

Blood culture

Candida spp.

CR providing sufficient details, 1 case of IFI among 2 cases with NE

[10]

PCS

5 (or more)

MNS

n.s.

dead

Blood culture / histology

Candida tropicalis 2 pts Candida albicans 1 pt Candida spp. 2 pts

Interesting autopsy series describing heterogeneity in the pathologic features of NE. Microbiologic data are not clearly linked to individual patients. No. of pat with IFI was not exactly described.

[51]

SCS

1

AA

OP

Dead

Histology

Candida spp. + bacteria

Acurate CS of 8 pat. with NE (1*IFI). Pat. were not consecutive.

[52]

CS2C

1

AA

NOP

Dead

Histology

Candida spp.

CR providing sufficient details

[53]

CS3C

1

HNHL

OP

survived

Histology

Candida spp.

Larger CS of 3 pat. with NE (1*IFI) among 56 pat. with abdominal complications necessitating surgery. Pat. were not consecutive.

[27]

MCS

1

HMNS

NOP

n.s.

Blood culture

Candida glabrata + Enterococcus spp.

Cohort study comparing 18 definite and 11 clinically diagnosed consecutive cases of NE. Substantial review.

[4]

MCS

2

AML ALL

NOP

dead

Blood culture 1 /histology 1

Aspergillus fumigatus 1 pt Candida krusei

Cohort study describing 13 consecutive cases of NE.

[54]

CS3C

1

AML

NOP

Dead

Histology

Cryptococcus neoformans

CR providing sufficient details of an uncommon course and pathogen

[17]

MCS

1

ALL

n.s.

Dead

Blood culture

Candida spp. (+Aspergillus ?)

Cohort study describing 13 consecutive cases of NE.

[55]

CS2C

1

MM

OP

Dead

Blood culture

Candida tropicalis + Staph.aureus + E.coli

CR providing sufficient details, 1 case of IFI among 2 cases of NE

[21]

CR

1

AML

NOP

Dead

Blood culture

Candida krusei

CR providing sufficient details

[20]

MCS

5

AML

OP 1pt n.s.4pts

Dead 1pt n.s.4 pts

Blood culture

Candida spp. 4 pts Candida guillermondi+ Trichosporon beigelii 1 pt

Cohort study describing 10 consecutive cases of NE.

[56]

MCS

2

AL

OP1 NOP1

Dead

Histology

Candida spp.

Case series describing 10 consecutive cases of NE. Patients were consecutive, but only patients with histologic confirmation were analysed.

[29]

MCS

1

AML

n.s.

survived

Blood culture

Candida albicans

Cohort study describing 7 consecutive cases of NE.

[57]

MCS

4

HMNS

n.s.

Dead

Histology

Candida spp.

Early large autopsy series. Relatively few individual patient data provided.

[58]

CR

1

NSCLC

OP

Dead

Peritoneal lavage

Candida albicans

CR providing sufficient details

[59]

CR

1

AML

OP

survived

Histology

Fungus n.s. + bacteria n.s.

Short but sufficiently detailled case report embedded in a review emphasizing nursing actions

[2]

SCS

3

MNS

NOP

Dead

Blood culture

Candida spp.

CS including 18 pat. with clinically diagosed NE (3*fungaemia) among 58 pat. with abdominal complications. Few patient details. Pat. were not consecutive.

[60]

PCS

2

AML

NOP

Dead

Histology

Candida spp.

Early smaller (6 patients with NE) but detailled autopsy case series.

[61]

RCS

2

AML

OP

Dead

Histology + Blood culture 1pt Histology 1pt

Candida spp. 1pt Candida spp.+ bacteria n.s. 1 pt

Smaller (6 patients with NE) but detailled radiological case series.

[62]

MCS

1 or more

HMNS

NOP

Dead

Histology

Fungus n.s

Cohort study describing 34 consecutive cases of NE. No. of pat with IFI was not exactly described.

[28]

SCS

1

LY

NOP

Dead

Histology

Candida spp.

Case series describing 22 patients with NE. Pat. were not consecutive. Relatively few individual microbiological data provided.Very good review.

Total 29

 

53

      
  1. ns, not specified; NE, neutropenic enterocolitis; IFI, invasive fungal infection; AML, acute myeloid leukaemia; ALL, acute lymphatic leukemia; MM, multiple myeloma;
  2. AL, acute leukaemia; CL, chronic leukemias; MNS, malignancy not specified; HMNS, haematological malignancy not specified; LY, lymphoma; NCCLC, non-small cell lung cancer; pts patients; OP, operated; NOP, not operated; CR, case report; CS3C, case series with 3 cases; MCS, medical case series; PCS, pathological case series; RCS radiological case series; SCS, surgical case series
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BMC Infectious Diseases

ISSN: 1471-2334

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