Table 1 Characteristics of clinical, immunological, and virological parameters of vertically HIV-1-infected children.
Responders | Non-Responders | |
|---|---|---|
N. of HIV-infected children | 33 | 127 |
Age (years) (a) | 5.9 (1.2; 15.7) | 5.7 (0.5; 14.9) |
Male (b) | 17 (51.5%) | 58 (45.6%) |
AIDS diagnosis (CDC) (b) | 13 (39.3%) | 58 (45.6%) |
Current immunological category (b) | ||
> 25% CD4+ | 8 (24.2%) | 40 (31.4%) |
15% – 25% CD4+ | 9 (27.2%) | 31 (24.4%) |
< 15% CD4+ | 16 (48.4%) | 52 (40.9%) |
Immunological parameters (a) | ||
% CD4+ | 12 (0.1; 35) | 18 (0.1; 52) |
CD4+/μL | 333 (4; 1207) | 440 (1; 2620) |
% CD8+ | 49 (22.1; 82) | 47 (13; 74.6) |
CD8+/μL | 927 (238; 3763) | 1006 (17; 6466) |
Virological characteristics | ||
log10 VL (copies/mL) (a) | 4.8 (3.7;6.4) | 4.8 (3.7; 6.5) |
VL ≤10,000 copies/mL (b) | 6 (18.1%) | 8 (6.2%) |
VL 10,000 to 30,000 copies/mL (b) | 7 (21.2%) | 28 (22.1%) |
VL 30,000 to 100,000 copies/mL (b) | 11 (33.3%) | 35 (27.5%) |
VL >100,000 copies/mL (b) | 9 (27.2%) | 56 (44.1%) |
ART prior to HAART | ||
ART-naïve HIV-infected children (b) | 13 (39.4%) | 17 (13.4%)* |
HIV-infected children with previous ART (b) | ||
Monotherapy | 15 (45.4%) | 71 (55.9%) |
Combined Therapy | 18 (54.5%) | 99 (77.9%)* |
Monotherapy + Combined Therapy | 20 (60.6%) | 110 (86.6%)* |
Time (months) with previous ART (a) | 25.9 (0; 75.8) | 22.4 (0; 114.1) |
Previous ART-protocol switches (a) | 2 (0; 4) | 2 (0; 5) |