Neonatal erythropoiesis and subsequent anemia in HIV-positive and HIV-negative Zimbabwean babies during the first year of life: a longitudinal study

Table 2 Anemia and iron status in Zimbabwean infants from birth through 6 months of age by HIV status of the mother and her infant.

Indicator	Birth	6 weeks	3 months	6 months
HIV status group
Serum ferritin, μg/L*
Nn group	199 (172,230)^a,b	131 (107,160)^a	52 (44,62)^a	15 (12,18)^a
n	108	63	64	75
Pn group	198 (181,216)^a	168 (153,185)^a	62 (56,69)^a	17 (15,19)^a
n	248	205	215	235
Pp group	251 (211,300)^b	320 (255,402)^b	141 (104,191)^b	36 (24,54)^b
n	76	70	52	40
P-value^†	0.036	<0.0001	<0.0001	<0.0001
Erythropoietin, U/L
Nn group	----------	10.2 (8.5,12.2)^a	12.2 (10.5,14.0)^a	16.2 (13.7,19.0)^a
n		62	60	74
Pn group		9.3 (8.4,10.2)^a	11.6 (10.7,12.5)^a	14.4 (13.0,15.8)^a
n		201	215	231
Pp group		16.3 (13.4,19.9)^b	23.4 (17.1,32.1)^b	26.1 (20.0,34.0)^b
n		69	53	38
P-value		<0.0001	<0.0001	<0.0001
Transferrin receptor, mg/L
Nn group	----------	3.5 (3.2,3.8)^a	6.2 (5.9,6.6)^a	6.8 (6.3,7.3)
n		63	64	75
Pn group		4.1 (4.0,4.3)^b	6.7 (6.4,7.0)^a	7.2 (6.9,7.6)
n		205	216	235
Pp group		4.7 (4.3,5.2)^c	8.2 (7.2,9.3)^b	8.0 (7.0,9.1)
n		71	53	40
P-value		<0.0001	0.0001	0.065

Abbreviations: Nn, mother HIV negative, baby HIV negative; Pn, mother HIV positive, baby HIV negative at 6 months; Pp, mother HIV positive, baby HIV positive at 6 weeks.
^a,b,c Means in a cell without a common letter differ, P < 0.05, Bonferroni multiple-comparison test.
* Values are geometric mean (95% CI).
† P-values are from analysis of variance of log-transformed values.

ISSN: 1471-2334