Table 3 Summary accuracy measures for commercial and in-house tests
Measure of test accuracy | Pooled summary measurea (95% CI) | Test for heterogeneityb p value |
|---|---|---|
All Commercial Tests [N = 14] | Â | Â |
Sensitivity | 0.62 (0.43, 0.77) | <0.001 |
Specificity | 0.98 (0.96, 0.98) | 0.12 |
Positive Likelihood Ratio (LR+) | 25.4 (16.2, 40.0) | 0.46 |
Negative likelihood Ratio (LR-) | 0.40 (0.24, 0.67) | <0.001 |
Diagnostic odds ratio (DOR) | 80.9 (34.4, 190.4) | 0.09 |
Amplicor [N = 4] | Â | Â |
Sensitivity | 0.37(0.24, 0.52) | 0.18 |
Specificity | 0.99 (0.97, 1.0) | 0.12 |
Positive Likelihood Ratio (LR+) | 52.8 (11.8, 236.2) | 0.14 |
Negative likelihood Ratio (LR-) | 0.59 (0.37, 0.95) | 0.20 |
Diagnostic odds ratio (DOR) | 105.5 (15.1, 733.9) | 0.10 |
LCx [N = 4] | Â | Â |
Sensitivity | 0.72 (0.54, 0.84) | 0.12 |
Specificity | 0.97 (0.95, 0.98) | 0.53 |
Positive Likelihood Ratio (LR+) | 25.6 (14.1, 46.4) | 0.57 |
Negative likelihood Ratio (LR-) | 0.32 (0.14, 0.68) | 0.09 |
Diagnostic odds ratio (DOR) | 93.2 (35.6, 243.7) | 0.38 |
MTD [N = 6] | Â | Â |
Sensitivity | 0.77 (0.62, 0.88) | <0.001 |
Specificity | 0.98 (0.96, 0.99) | 0.66 |
Positive Likelihood Ratio (LR+) | 17.4 (6.1, 49.7) | 0.26 |
Negative likelihood Ratio (LR-) | 0.31 (0.09, 1.03) | <0.001 |
Diagnostic odds ratio (DOR) | 72.9 (9.9, 533.4) | 0.03 |
In-house Tests [N = 26] | Â | Â |
Sensitivity | 0.71 (0.63, 0.78) | <0.001 |
Specificity | 0.93 (0.88, 0.96) | <0.001 |
Positive Likelihood Ratio (LR+) | 9.7 (5.7, 16.6) | <0.001 |
Negative likelihood Ratio (LR-) | 0.32 (0.23, 0.43) | <0.001 |
Diagnostic odds ratio (DOR) | 42.4 (22.2, 81.1) | <0.001 |