Compound | Concentration |
|---|
| | 25 µg/mL | 50 µg/mL |
|---|
| | titer (pfu/mL) | % inhibition | titer (pfu/mL) | % inhibition |
|---|
TNapPS | 3.5 × 105
| 98 | 2.6 × 105
| 98 |
TAnthPS | 3.0 × 106
| 81 | 5.8 × 105
| 96 |
CuHPIX | 1.1 × 106
| 93 | 4.5 × 105
| 97 |
CuPcS(3444) | 6.3 × 106
| 60 | 4.1 × 106
| 74 |
ZnPPIX | 2.5 × 105
| 98 | 1.0 × 105
| 99 |
-
aCV-1 cells were infected with the WR strain at 2.5 pfu/cell and then media containing compounds at 50 or 25 µg/mL were added; at 16 h post-infection, the cells and media were collected for virus titration by plaque assay. % inhibition = (1 - TA/TB) × 100 where TA is the average virus titer in the presence of the tetrapyrrole and TB is the virus titer where no compound was added (control). Virus titer in the control was 1.6 × 107 pfu/mL. Data are means of duplicate experiments.
