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Table 2 HRHPV Hybrid Capture II performance for the diagnosis of CIN2/3

From: Evaluation of adjunctive HPV testing by Hybrid Capture II®in women with minor cytological abnormalities for the diagnosis of CIN2/3 and cost comparison with colposcopy

referral smear

cut off

n

sensitivity

specificity

NPV

NLR

OR

MD & BL

1 RLU

133

97%

37%

97%

0.089

17

MD & BL

3 RLU

133

97%

46%

98%

0.072

26

1xMD

1 RLU

110

97%

36%

97%

0.096

17

1xMD

3 RLU

110

97%

41%

97%

0.083

19

3xBL

1 RLU

23

100%

52%

100%

NA

NA

3xBL

3 RLU

23

100%

64%

100%

NA

NA

MD & BL in woman >30y

1 RLU

66

100%

47%

100%

NA

NA

MD & BL in woman >30y

3 RLU

66

100%

58%

100%

NA

NA

  1. MD = mild dyskaryosis, BL= borderline, NA = non applicable due to 0 in 2 × 2 table