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Table 3 Treatment uptake as defined by percentage of hepatitis C RNA-positive study participants who received treatment

From: A systematic review of Hepatitis C virus treatment uptake among people who inject drugs in the European Region

Author, year

% treated (# treated/# of treatment candidates)

SVR (%) (# with sustained viral response/# treated)

Backmund et al, 2001

50% (50/100)

Intent-to-treat: 36% (18/50)

Broers et al, 2005

61% (11/18)

Intent-to-treat: 56% (6/11)

As-treated: 100% (3/3)

Cournot et al, 2004

54% (81/151)

Intent-to-treat: 26% (26/99)1

Cullen et al, 2007

10% (3/29)

NA

Ebner et al, 2009

23% (17/75)

Intent-to-treat: 88% (15/17)

As-treated: 88% (15/17)

Gazdag et al, 2010

47% (39/83)

NA

Grando-Lemaire et al, 2002

28% (27/97)

Intent-to-treat: 19% (5/27)

As-treated: 33% (5/15)

Guadagnino et al, 2007

31% (53/169)

Intent-to-treat: 55% (29/53)

As-treated: 85% (29/34)

Hernandez et al, 2009

0% (0/4)

NA

Jack et al, 2009

25% (30/118)

Intent-to-treat: 62% (13/21)

As-treated: 77% (13/17)

Jowett et al, 2000

29% (50/172)

Intent-to-treat: 36% (18/50)

Kieran et al, 2011

21% (67/327)

Intent-to-treat: 43% (29/67)

Lindenburg et al, 2011

30% (58/196)

Intent-to-treat: 65% (37/57)

As-treated: 77% (37/48)

McCormick et al, 2008

46% (6/13)

Intent-to-treat: 83% (5/6)

As-treated: 83% (5/6)

Moussalli et al, 20102

2% (2/113)

NA

Moussalli et al, 20102

38% (85/224)

Intent-to-treat: 43% (37/85)

Perez-Alvarez et al, 2012

56% (15/27)

NA

Perut et al, 2009

9% (12/137)

NA

Reiberger et al, 2011

32% (201/637)

NA

van der Veen, 2009

48% (35/73)

NA

Wilkinson et al, 2008

14% (63/441)

As-treated: 51% (25/49)3

Witteck et al, 2011

15% (29/193)

Intent-to-treat: 52% (13/25)

  1. 1. Calculated according to the number of treatment outcomes (N=99) rather than the number of patients who initiated therapy (N=81)
  2. 2. The study by Moussalli et al includes separate study populations for an observational phase (N=113) and an intervention phase (N=224), and those study populations are represented by two separate records in this table.
  3. 3. Calculated according to the number of treatment outcomes (N=49) rather than the number of patients who completed therapy (N=58)