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Table 2 Summary of subgroup analysis of the included studies by different study characteristics

From: Significance of serum procalcitonin as biomarker for detection of bacterial peritonitis: a systematic review and meta-analysis

Variables

No. of studies

No. of patients

Sensitivity (95% CI)

Specificity (95% CI)

Diagnostic OR (95% CI)

AUROC (95% CI)

I 2(95% CI)

Likelihood ratio (95% CI)

Publication bias (Deek’s test P)

Positive

Negative

Serum PCT

          

Overall analysis

17

1644

0.83(0.76-0.89)

0.92(0.87-0.96)

61.52(27.58-137.21)

0.94(0.92-0.96)

90.08(80.35-99.81)

11.06(6.31-19.38)

0.18(0.12-0.27)

0.973

PD patients

4

391

0.64(0.47-0.78)

0.91(0.85-0.94)

18.33(6.32-53.12)

0.89(0.87-0.92)

0.00(0.00-100.00)

7.19(3.75-13.82)

0.39(0.24-0.62)

0.629

Cirrhotic patients

11

807

0.86(0.81-0.89)

0.94(0.85-0.97)

85.89(27.31-270.19)

0.91(0.89-0.94)

80.65(58.51-100.00)

13.17(5.27-32.86)

0.15(0.11-0.21)

0.734

High cut-off PCT valuea

9

640

0.68(0.44-0.85)

0.97(0.91-0.99)

60.01(24.19-148.85)

0.95(0.93-0.97)

97.33(95.53-99.13)

20.02(8.29-48.37)

0.33(0.17-0.64)

0.813

Low cut-off PCT valueb

3

529

0.85(0.80-0.88)

0.89(0.79-0.94)

42.57(19.72-91.89)

0.86(0.83-0.89)

61.42(13.01-100.00)

7.42(3.89-14.17)

0.17(0.13-0.23)

0.299

Common PCT cut-off valuec

9

1072

0.81(0.68-0.89)

0.95(0.89-0.98)

75.32(21.13-268.52)

0.95(0.93-0.97)

15.30(0.00-100.00)

15.35(6.67-35.28)

0.20(0.12-0.35)

0.973

Common PCT cut-off in PD

4

391

0.64(0.47-0.78)

0.91(0.85-0.94)

18.33(6.32-53.12)

0.89(0.87-0.92)

0.00(0.00-100.00)

7.19(3.75-13.82)

0.39(0.24-0.62)

0.629

Common PCT cut-off in SBP

5

681

0.87(0.78-0.92)

0.97(0.85-0.99)

245.08(26.73-2247.33)

0.94(0.92-0.96)

60.35(10.58-100.00)

33.02(5.06-215.47)

0.13(0.07-0.23)

0.562

Publication in Chinese

8

905

0.86(0.81-0.89)

0.95(0.89-0.98)

141.09(42.44-469.04)

0.93(0.90-0.95)

30.79(0.00-100.00)

20.12(7.64-52.94)

0.14(0.10-0.19)

0.493

Publication in English

9

739

0.79(0.63-0.89)

0.89(0.81-0.94)

29.16(11.78-72.17)

0.92(0.89-0.94)

91.95(84.48-99.43)

6.99(3.97-12.28)

0.24(0.13-0.44)

0.683

FAS > 0.1 ng/ml

9

704

0.82(0.71-0.90)

0.93(0.85-0.97)

65.43(17.30-247.48)

0.95(0.92-0.96)

48.24(0.00-100.00)

12.26(5.01-29.99)

0.18(0.10-0.33)

0.508

FAS ≤ 0.1 ng/ml

8

940

0.86(0.76-0.92)

0.92(0.85-0.96)

71.41(43.93-116.09)

0.95(0.93-0.97)

89.60(79.27-99.92)

10.76(6.01-19.26)

0.15(0.08-0.26)

0.786

Ascitic PCT

          

Overall analysis

5

418

0.79(0.54-0.92)

0.96(0.81-0.99)

80.93(15.26-429.28)

0.96(0.94-0.97)

77.94(52.08-100.00)

17.85(4.11-77.59)

0.22(0.09-0.54)

0.075

Serum CRP

          

Overall analysis

7

499

0.76(0.58-0.88)

0.81(0.63-0.92)

13.54(7.25-25.28)

0.85(0.82-0.88)

96.81(94.54-99.09)

4.01(2.16-7.45)

0.29(0.17-0.49)

0.676

  1. Note: PCT procalcitonin, PD peritoneal dialysis, CRP C-reactive protein, SBP Spontaneous bacterial peritonitis, FAS functional assay sensitivities, AUROC area under the receiver operating characteristic curve.
  2. aHigh cut-off valu: greater than 0.5 ng/ml; bLow cut-off value: lesser than 0.5 ng/ml; cCommon PCT Cut-off value: = 0.5 ng/ml.
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BMC Infectious Diseases

ISSN: 1471-2334

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