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Table 6 Associations between infection by different M. tuberculosis sublineages (according to the SpolDB4[23]) and clinical manifestations

From: Increased level of acute phase reactants in patients infected with modern Mycobacterium tuberculosis genotypes in Mwanza, Tanzania

Groups

Reference group: EAI5 (n = 33)

CAS_KILI (n = 44)

LAM11_ZWE (n = 51)

Variables

Regression coefficient

95% CI

P-value

Regression coefficient

95% CI

P-value

Age (years)1

1.8

[-4.55 – 8.06]

0.58

-0.6

[-6.84 – 5.68]

0.86

Weight (kg/m2)2

-1.0

[-4.37 – 2.48]

0.59

-3.0

[-6.39 – 0.40]

0.08

BMI (kg/m2)2

-0.5

[-1.62 – 0.67]

0.41

-0.9

[-2.07 – 0.19]

0.10

CRP (mg/L)2

13.2

[-11.26 – 37.66]

0.29

24.4

[0.24 – 48.63]

0.05

AGP (g/L)1*

0.2

[-0.15 – 0.62]

0.23

0.4

[-0.01 – 0,73]

0.06

Neutrophil count (x 109 cells/L)2

-0.1

[-0.93 – 0.69]

0.77

0.9

[0.09 – 1.70]

0.03

Lymphocyte count(x 109 cells/L)2

0.4

[-0.02 – 0.91]

0.06

0.3

[-0.18 – 0.74]

0.23

CD4 count (cells/ul)2

38.8

[-91.88 – 169.46]

0.56

-13.0

[-142.54 – 116.53]

0.84

Hemoglobin (g/dl)2

0.1

[-0.90 – 1.12]

0.83

-0.4

[-1.40 – 0.60]

0.43

Fasting blood glucose (mmol/L)2

-0.1

[-0.52 – 0.30]

0.60

-0.3

[-0.68 – 0.14]

0.19

Diabetes2

1.3

[0.35 – 4.99]

0.68

1.1

[0.28 – 4.22]

0.89

Smoking2

1.4

[0.44 – 4.22]

0.60

1.3¶

[0.41 – 4.19]

0.64

TB contact2

1.1

[0.39 – 3.12]

0.85

1.3¶

[0.46 – 3.44]

0.66

BCG scar2

1.2

[0.40 – 3.51]

0.76

1.5¶

[0.51 – 4.60]

0.44

  1. Results are based on a linear and logistic regression models adjusted for age, sex and HIV status.
  2. 1Adjusted for HIV status and gender.
  3. 2Adjusted for HIV status, age and gender.
  4. 3 P-values <0.05 are in bold.
  5. *HIV negative only.
  6. ¶Odds ratio.
  7. BMI: Body Mass Index.
  8. EAI: East-African Indian.
  9. CRP: C-reactive protein.
  10. AGP: Orosomucoid.
  11. BCG: Bacillus Calmette-Guerrin.