Serum biomarkers predictive of cure in Chagas disease patients after nifurtimox treatment

BMC Infectious Diseases

Table 2 Expression patterns of selected biomarkers in 2011 follow-up samples compared to 2008 Chagasic patients treated with nifurtimox (Upward arrow: up-regulated; Downward arrow: down-regulated)

Nfx days	Sample Lab ID	9.3 kDa	13.6 kDa	24.7 kDa	28.1 kDa	28.9 kDa	2008 ELISA OD	2011 ELISA OD	2011 ELISA	2011 PCR	2011 RT-PCR	Cured (C) Not Cured (NC)
60	54	↓	↓	↓	↑	↓	0.62	0.62	+	-	-	C
60	56	↓	↓	↓	↑	↓	2.53	2.02	+	-	-	C
60	57	↓	↓	↓	↑	↓	0.41	0.50	+	-	-	C
60	59	↓	↑	↓	↑	↓	2.37	2.17	+	-	-	C
60	60	↑	↑	↑	↓	↑	2.80	2.57	+	-	-	NC
60	62	↓	↓	↑	↑	↓	2.55	2.11	+	-	-	NC
60	65	↓	↓	↑	↑	↓	0.79	0.61	+	-	-	NC
60	68	↓	↑	↓	↓	↓	1.88	1.53	+	-	-	NC
60	69	↓	↓	↑	↑	↓	1.84	1.75	+	-	-	NC
60	70	↓	↑	↑	↑	↓	1.11	1.23	+	-	-	NC
60	71	↑	↑	↑	↓	↑	1.64	1.19	+	-	+	NC
60	72	↓	↓	↓	↑	↓	1.47	1.67	+	-	-	C
60	77	↓	↑	↓	↑	↓	2.16	1.58	+	-	-	C
60	84	↓	↑	↓	↑	↓	2.94	2.49	+	-	-	C
60	85	↓	↑	↑	↓	↓	1.76	2.11	+	-	-	NC
60	86	↑	↓	↓	↑	↓	2.18	2.25	+	-	-	NC
60	87	↓	↓	↓	↑	↓	1.95	1.89	+	-	-	C
60	91	↓	↓	↑	↑	↓	2.16	1.83	+	-	-	NC
60	94	↓	↓	↓	↑	↓	2.07	1.93	+	-	-	C
60	97	↓	↓	↑	↑	↓	2.26	1.85	+	-	-	NC
60	99	↓	↑	↓	↑	↓	1.69	1.25	+	-	-	C
60	100	↓	↓	↓	↑	↓	2.17	1.79	+	-	-	C
60	102	↓	↓	↓	↑	↓	2.61	1.31	+	-	-	C
60	103	↑	↓	↑	↓	↑	2.56	2.28	+	-	-	NC
60	104	↓	↓	↓	↑	↓	2.78	1.97	+	-	-	C
58	64	↓	↓	↓	↑	↑	2.55	2.27	+	-	-	C
47	67	↓	↓	↓	↑	↓	1.83	1.90	+	-	-	C
31	58	↑	↑	↑	↓	↑	2.28	1.91	+	-	-	NC
21	80	↓	↑	↓	↑	↓	2.42	1.78	+	-	-	C
21	81	↑	↑	↑	↓	↑	2.16	1.70	+	-	-	NC
21	88	↑	↑	↑	↓	↑	2.02	1.64	+	-	-	NC
19	96	↑	↑	↑	↓	↑	1.99	2.42	+	-	-	NC
16	90	↓	↑	↑	↓	↓	1.44	1.02	+	-	-	NC
14	95	↑	↑	↑	↓	↑	1.13	2.24	+	-	-	NC
10	66	↑	↑	↑	↓	↑	2.35	1.92	+	-	-	NC
10	73	↑	↑	↑	↓	↑	2.21	2.00	+	-	-	NC
2	55	↑	↑	↑	↓	↑	2.65	2.82	+	-	-	NC

ISSN: 1471-2334