Table 5 Adjusted incidence rate ratios and 95% confidence intervals for factors associated with AIDS-related events, non-AIDS-related events, and deaths (ANRS CO3 Aquitaine and IPEC/FIOCRUZ cohorts combined, 2000–2008)

Cohort: IPEC (vs. Aquitaine)

1.09 (0.91, 1.3)

0.53 (0.46, 0.62)

1.17 (0.94, 1.47)

0.37 (0.24, 0.55)

0.78 (0.52, 1.17)

Calendar year (per year)

1.03 (0.99, 1.06)

1.02 (1.0, 1.05)

1.03 (1.0, 1.07)

1.04 (0.98, 1.09)

1.05 (0.98, 1.12)

Age (in years)

<30 years

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

30-39

0.95 (0.72, 1.26)

1.05 (0.83, 1.33)

1.34 (0.98, 1.83)

1.28 (0.76, 2.17)

0.8 (0.39, 1.65)

40-49

0.81 (0.61, 1.08)

1.12 (0.88, 1.44)

1.18 (0.85, 1.64)

1.18 (0.7, 2.01)

1.52 (0.78, 2.99)

50-59

0.59 (0.42, 0.83)

1.24 (0.94, 1.65)

1.13 (0.78, 1.64)

0.95 (0.5, 1.78)

1.48 (0.67, 3.28)

≥60

0.93 (0.61, 1.4)

2.16 (1.58, 2.97)

1.9 (1.24, 2.89)

1.14 (0.54, 2.38)

3.09 (1.13, 8.49)

Sex: Female (vs. Male)

0.9 (0.76, 1.07)

1.01 (0.88, 1.15)

0.95 (0.79, 1.15)

1.06 (0.81, 1.37)

0.98 (0.63, 1.52)

IDU: Yes (vs. No)

1.03 (0.78, 1.36)

1.42 (1.18, 1.7)

1.01 (0.75, 1.34)

3.14 (2.29, 4.3)

1.49 (0.89, 2.49)

CD4 cell count (cells/mm³)

>500

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

351-500

3.47 (2.19, 5.51)

1.28 (1.07, 1.53)

1.24 (0.95, 1.61)

0.96 (0.67, 1.38)

2.42 (1.44, 4.08)

201-350

9.05 (5.91, 13.88)

2.25 (1.89, 2.67)

1.85 (1.43, 2.4)

1.98 (1.44, 2.73)

4.87 (2.97, 7.99)

51-200

31.83 (20.81, 48.71)

4.34 (3.59, 5.24)

3.94 (2.95, 5.26)

2.59 (1.76, 3.79)

9.52 (5.56, 16.29)

≤50

111.45 (70.13, 177.11)

10.99 (8.66, 13.94)

9.14 (6.37, 13.12)

4.98 (2.96, 8.37)

22.31 (11.27, 44.15)

HIV viral load (copies/mL)

≤400

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

401-3000

1.58 (1.14, 2.17)

1.3 (1.09, 1.54)

1.41 (1.09, 1.83)

1.08 (0.75, 1.57)

1.28 (0.76, 2.17)

3001-10000

1.6 (1.11, 2.29)

1.45 (1.18, 1.76)

1.12 (0.83, 1.52)

1.87 (1.25, 2.81)

1.71 (0.86, 3.4)

10001-100000

2.3 (1.76, 3.01)

1.76 (1.5, 2.06)

1.96 (1.54, 2.49)

2.02 (1.44, 2.84)

1.53 (0.96, 2.43)

>100000

4.39 (3.33, 5.8)

2.61 (2.15, 3.16)

2.79 (2.12, 3.68)

2.89 (1.93, 4.33)

2.18 (1.21, 3.92)

≤1 year since HIV + test: Yes (vs. No)

3.87 (3.19, 4.71)

1.99 (1.69, 2.35)

1.51 (1.16, 1.97)

1.04 (0.65, 1.67)

2.74 (1.84, 4.1)

On cART: Yes (vs. No)

2.15 (1.23, 3.74)

2.5 (1.82, 3.44)

1.58 (1.04, 2.41)

2.21 (1.12, 4.38)

3.72 (1.5, 9.2)

Hepatitis B positive (vs. not)

1.03 (0.77, 1.39)

1.17 (0.93, 1.47)

1.23 (0.9, 1.68)

0.92 (0.57, 1.5)

1.93 (1.16, 3.18)

Hepatitis C positive (vs. not)

0.95 (0.74, 1.23)

1.7 (1.45, 2.0)

1.91 (1.52, 2.4)

1.73 (1.29, 2.32)

5.18 (3.29, 8.14)

Non-AIDS

Death

Viral

Neurological

Cardiovascular

Parasitic

Cohort: IPEC (vs. Aquitaine)

0.52 (0.38, 0.7)

0.06 (0.03, 0.12)

1.13 (0.76, 1.68)

0.17 (0.09, 0.3)

1.01 (0.79, 1.28)

Calendar year (per year)

0.95 (0.9, 1.0)

0.96 (0.9, 1.02)

1.01 (0.94, 1.1)

1.04 (0.98, 1.11)

1 (0.96, 1.04)

Age (in years)

<30 years

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

30-39

0.93 (0.6, 1.44)

1.1 (0.55, 2.21)

0.93 (0.39, 2.19)

1.07 (0.59, 1.94)

1.76 (0.92, 3.35)

40-49

0.82 (0.51, 1.31)

1.41 (0.67, 2.93)

1.72 (0.74, 4)

0.89 (0.48, 1.65)

2.18 (1.15, 4.14)

50-59

0.76 (0.44, 1.32)

1.55 (0.72, 3.33)

2.4 (0.99, 5.81)

0.85 (0.43, 1.67)

3.25 (1.69, 6.25)

>60

0.94 (0.47, 1.85)

3.13 (1.41, 6.97)

5.27 (2.14, 12.93)

1.19 (0.42, 3.35)

6.55 (3.32, 12.92)

Sex: Female (vs. Male)

1.26 (0.98, 1.62)

1.04 (0.74, 1.47)

0.94 (0.65, 1.35)

1.2 (0.85, 1.69)

0.66 (0.51, 0.85)

IDU: Yes (vs. No)

1.07 (0.77, 1.48)

2.01 (1.29, 3.12)

1.55 (0.97, 2.46)

1.08 (0.71, 1.64)

1.29 (0.93, 1.78)

CD4 cell count (cells/mm³)

>500

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

351-500

0.81 (0.55, 1.18)

1.48 (0.94, 2.33)

2.00 (1.23, 3.24)

1.79 (0.85, 3.75)

1.44 (0.99, 2.08)

201-350

1.76 (1.25, 2.48)

2.3 (1.52, 3.46)

2.06 (1.22, 3.47)

3.82 (1.88, 7.76)

2.25 (1.6, 3.18)

51-200

2.8 (1.9, 4.11)

5.76 (3.58, 9.26)

4.64 (2.66, 8.12)

11.73 (5.9, 23.32)

6.33 (4.5, 8.89)

≤50

9.71 (6.07, 15.52)

13.6 (7.55, 24.49)

15.9 (8.13, 31.28)

29.59 (13.83, 63.28)

27.32 (18.44, 40.47)

HIV viral load (copies/mL)

≤400

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

1 (Ref.)

401-3000

1.38 (0.94, 2.02)

1.51 (0.98, 2.33)

0.91 (0.52, 1.59)

2.22 (1.11, 4.48)

0.91 (0.64, 1.31)

3001-10000

1.65 (1.07, 2.53)

1.91 (1.23, 2.97)

1.13 (0.6, 2.1)

3.09 (1.52, 6.31)

1.03 (0.68, 1.56)

10001-100000

2.52 (1.83, 3.46)

1.63 (1.11, 2.38)

1.18 (0.77, 1.8)

4.88 (2.9, 8.21)

1.08 (0.81, 1.44)

>100000

3.13 (2.1, 4.65)

2.49 (1.59, 3.9)

1.15 (0.67, 1.99)

8.03 (4.51, 14.29)

1.49 (1.07, 2.09)

≤1 year since HIV + test: Yes (vs. No)

2.72 (1.93, 3.83)

1.17 (0.67, 2.03)

1.67 (0.96, 2.93)

4.51 (3.14, 6.47)

0.85 (0.53, 1.37)

On cART: Yes (vs. No)

2.45 (1.3, 4.6)

8.3 (1.95, 35.33)

3.86 (1.17, 12.8)

7.62 (1.75, 33.26)

0.85 (0.5, 1.47)

Hepatitis B positive (vs. not)

0.98 (0.61, 1.59)

1.07 (0.6, 1.91)

1.05 (0.61, 1.8)

1.31 (0.73, 2.37)

1.96 (1.44, 2.66)

Hepatitis C positive (vs. not)

1.11 (0.82, 1.51)

1.02 (0.65, 1.58)

1.31 (0.89, 1.94)

1.26 (0.85, 1.87)

1.79 (1.34, 2.38)