Table 4 Cost effectiveness (cost per life years saved) of vaccination strategies for moderate pandemics (R = 1.9 and CFR = 0.25%) and severe pandemics (R = 2.7 and CFR = 1.5%)
From: A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness
|  | Moderate pandemics (R = 1.9 and CFR = 0.25%) | ||
|---|---|---|---|
Scenarios | SD and AV intervention | Cost ($) per LYS | |
Pre-emptive vaccination | Reactive vaccination | ||
Scenario 1: no pandemic occurs | none | - | - |
|  | Pre-emptive + Reactive vaccination | Reactive vaccination | |
Scenario 2: pandemic with virus which does not match pre-emptive vaccine i.e. vaccine efficacy of 0% | none | $1,627,500 | $1,020,000 |
8 weeks SD + AV | $29,684 | $20,079 | |
Sustained SD + AV | $24,846 | $19,074 | |
| Â | Pre-emptive vaccination | Reactive vaccination | |
Scenario 3: pandemic with virus which matches pre-emptive vaccine with efficacy of 30% | none | $13,622 | $1,020,000 |
8 weeks SD + AV | $12,096 | $20,079 | |
Sustained SD + AV | $15,897 | $19,074 | |
| Â | Pre-emptive vaccination | Reactive vaccination | |
Scenario 4: pandemic with virus which matches pre-emptive vaccine with efficacy of 75% | none | $8,013 | $1,020,000 |
8 weeks SD + AV | $10,435 | $20,079 | |
Sustained SD + AV | $13,658 | $19,074 | |
|  | Extreme pandemics (R = 2.7 and CFR = 1.5%) | ||
Scenarios | SD and AV intervention | Cost ($) per LYS | |
Pre-emptive vaccination | Reactive vaccination | ||
Scenario 1: no pandemic occurs | none | - | - |
|  | Pre-emptive + Reactive vaccination | Reactive vaccination | |
Scenario 2: pandemic with virus which does not match pre-emptive vaccine i.e. vaccine efficacy of 0% | none | $1,942,222 | $1,672,222 |
8 weeks SD + AV | $12,305 | $10,312 | |
Sustained SD + AV | $4,938 | $4,044 | |
| Â | Pre-emptive vaccination | Reactive vaccination | |
Scenario 3: pandemic with virus which matches pre-emptive vaccine with efficacy of 30% | none | $6,066 | $1,672,222 |
8 weeks SD + AV | $3,097 | $10,312 | |
Sustained SD + AV | $2,811 | $4,044 | |
| Â | Pre-emptive vaccination | Reactive vaccination | |
Scenario 4: pandemic with virus which matches pre-emptive vaccine with efficacy of 75% | one | $1,075 | $1,672,222 |
8 weeks SD + AV | $1,454 | $10,312 | |
Sustained SD + AV | $1,986 | $4,044 | |