Table 3 Total cost of vaccination strategies for moderate pandemics (R = 1.9 and CFR = 0.25%) and severe pandemics (R = 2.7 and CFR = 1.5%)
From: A model-based economic analysis of pre-pandemic influenza vaccination cost-effectiveness
|  | Moderate pandemics (R = 1.9 and CFR = 0.25%) | ||
|---|---|---|---|
Scenarios | SD and AV intervention | Total cost ($) per 10,000 population | |
Pre-emptive vaccination | Reactive vaccination | ||
Scenario 1: no pandemic | none | $2,430,000 | $0 |
|  | Pre-emptive + Reactive vaccination | Reactive vaccination | |
Scenario 2: pandemic with virus which does not match pre-emptive vaccine i.e. vaccine efficacy of 0% | none | $6,510,000 | $4,080,000 |
8 weeks SD + AV | $7,510,000 | $5,080,000 | |
Sustained SD + AV | $10,460,000 | $8,030,000 | |
Unmitigated pandemic cost (no intervention) | $3,200,000 | ||
| Â | Pre-emptive vaccination | Reactive vaccination | |
Scenario 3: pandemic with virus which matches pre-emptive vaccine with efficacy of 30% | none | $4,250,000 | $4,080,000 |
8 weeks SD + AV | $5,020,000 | $5,080,000 | |
Sustained SD + AV | $6,820,000 | $8,030,000 | |
Unmitigated pandemic cost (no intervention) | $3,200,000 | ||
| Â | Pre-emptive Vaccination | Reactive vaccination | |
Scenario 4: pandemic with virus which matches pre-emptive vaccine with efficacy of 75% | none | $3,630,000 | $4,080,000 |
8 weeks SD + AV | $4,800,000 | $5,080,000 | |
Sustained SD + AV | $6,310,000 | $8,030,000 | |
Unmitigated pandemic cost (no intervention) | $3,200,000 | ||
|  | Extreme pandemics (R = 2.7 and CFR = 1.5%) | ||
Scenarios | SD and AV intervention | Total cost ($) per 10,000 population | |
Pre-emptive vaccination | Reactive vaccination | ||
Scenario 1: no pandemic | none | $2,430,000 | $0 |
|  | Pre-emptive + Reactive vaccination | Reactive vaccination | |
Scenario 2: pandemic with virus which does not match pre-emptive vaccine i.e. vaccine efficacy of 0% | none | $17,480,000 | $15,050,000 |
8 weeks SD + AV | $15,000,000 | $12,570,000 | |
Sustained SD + AV | $13,430,000 | $11,000,000 | |
Unmitigated pandemic cost (no intervention) | $14,180,000 | ||
| Â | Pre-emptive vaccination | Reactive vaccination | |
Scenario 3: pandemic with virus which matches pre-emptive vaccine with efficacy of 30% | none | $10,190,000 | $15,050,000 |
8 weeks SD + AV | $8,420,000 | $12,570,000 | |
Sustained SD + AV | $8,810,000 | $11,000,000 | |
Unmitigated pandemic cost (no intervention) | $14,180,000 | ||
| Â | Pre-emptive vaccination | Reactive vaccination | |
Scenario 4: pandemic with virus which matches pre-emptive vaccine with efficacy of 75% | none | $3,760,000 | $15,050,000 |
8 weeks SD + AV | $5,100,000 | $12,570,000 | |
Sustained SD + AV | $6,970,000 | $11,000,000 | |
Unmitigated pandemic cost (no intervention) | $14,180,000 | ||