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Table 1 The IC 50 of 5 viruses and FC contrasted with pNL4-3 W T

From: Impact of Y181C and/or H221Y mutation patterns of HIV-1 reverse transcriptase on phenotypic resistance to available non-nucleoside and nucleoside inhibitors in China

Virus

IC50 a ± SD (nM) (FCb)

NVP

EFV

AZT

3TC

d4T

WTpNL4–3

74.49 ± 9.24 (1.0)

13.66 ± 7.74 (1.0)

21.42 ± 16.84 (1.0)

44.60 ± 31.99 (1.0)

275.20 ± 118.69(1.0)

K101Q/Y181C/H221Y

93400.00 ± 32831.88*(1253.9)

68.33 ± 12.95*(5.0)

40.90 ± 13.55 (1.9)

102.38 ± 30.42 (2.3)

727.55 ± 157.47 (1.9)

K101Q/Y181C

73470.00 ± 20855.22*(986.4)

40.46 ± 15.70 (3.0)

10.26 ± 4.34 (0.5)

79.17 ± 3.56 (1.2)

373.33 ± 214.30 (1.4)

K101Q/H221Y

294.63 ± 80.62 (4.0)

0.54 ± 0.32*(0.04)

222.10 ± 49.35*(10.4)

496.8 ± 115.53*(11.1)

5715.00 ± 610.50*(20.8)

K101Q

56.63 ± 11.36 (0.8)

5.17 ± 1.44 (0.4)

52.34 ± 11.93 (2.4)

82.58 ± 62.18 (1.9)

322.90 ± 119.67 (1.2)

  1. a, the 50% inhibitory concentration. b, calculated by dividing the IC50 of each mutant virus by the IC50 for the wild-type. The mean ± SD of three independent experiments. FC only showed the mean of three independent experiments. * IC50 was significantly change compared with pNL4-3 WT , P < 0.05.
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BMC Infectious Diseases

ISSN: 1471-2334

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