Table 3 Influence of factors on adherence for factors that were analyzed in one study
From: Factors influencing adherence in Hepatitis-C infected patients: a systematic review
Study | Factor | Effect direction or compared categories; effect size; 95%-CI or p-value |
|---|---|---|
Giannelli 2012 [21]* | Anemia | Negative; NR; < 0.05 |
Lo Re [4] | Methadone use | Yes vs. no; OR = 0.99; 0.167 |
New use of growth factors | Yes vs. no; OR = 1.01; 0.021 | |
New use of thyroid medication | Yes vs. no; OR = 1.02; 0.022 | |
Schizophrenia | Yes vs. no; OR = 1.00; 0.605 | |
Marcellin 2011 [8]* | Adverse events | Yes vs. no; OR# = 1.09; 0.77 to 1.54 |
Diabetes (baseline and follow-up) | NR; NR; > 0.05 | |
Duration of infection | Positive; NE; 0.601# | |
Fibrosis scores | NR; NR; > 0.05 | |
HCB positive | Yes vs. no; OR# = 1.47; 0.62 to 3.48 | |
Naïve for Hepatitis-C virus treatment | Yes vs. no; OR = 1.32; 1.03 to 1.69 | |
Origin of incomes | Paid employment vs. others; OR# =1.12; 0.91 to 1.38 | |
Other chronic disease (baseline) | Yes vs. no; OR# = 0.91; 0.72 to 1.15 | |
Remoteness of the center (transport time) | Per min; OR = 1.00; 1.00 to 1.01 | |
Source of Hepatitis-C virus infection | Intra venous drug use vs. others; OR# = 0.99; 0.80 to 1.22 | |
Therapeutic education (not specified) | NR; NR; > 0.05 | |
Sola [24]* | Alanin-Aminotransferase | NR; NR; > 0.05 |
Alkaline phosphatase | NR; NR; > 0.05 | |
Aspartate aminotransferase | NR; NR; > 0.05 | |
Fibrosis metavir score | NR; NR; > 0.05 | |
Leukocytes | Positive; NE; 0.007# | |
Platelets | NR; NR; > 0.05 | |
Prothrombin time | NR; NR; > 0.05 | |
Serum albumin | NR; NR; > 0.05 | |
Serum bilirubin | NR; NR; > 0.05 | |
Sylvestre [25]*# | Duration of abstinence | ≥ 1 month vs. < 1 month; MD = 27%; 0.10 |
Psychiatric medication (baseline) | NR; NR; 0.2 | |
Psychiatric medication (during treatment) | NR; NR; 0.3 | |
Psychiatric medication (initiation during treatment) | Yes vs. no; MD = -28%; 0.02 | |
Tanioka [26] | Physicians experience (years) | ≥ 19 vs. < 19; RR = 1.54; 0.96 to 2.48 |
Platelet count (104/ml) | ≥ 15 vs. < 15; RR# = 0.86; 0.57 to 1.29 | |
Treatment center size (cases per center) | ≥ 15 vs. < 15; RR = 1.65; 1.04 to 2.64 | |
White blood cell count (ml) | ≥ 5000 vs. < 5000; RR# = 1.16; 0.77 to 1.75 | |
Wagner [27]*# | Drinking problem | Yes vs. no; OR = 0.63; 0.16 to 2.44 |
HIV RNA | ≤ 400 vs. >400; OR = 1.83; 0.51 to 6.53 | |
In a relationship | Yes vs. no; OR = 0.81; 0.24 to 2.75 |