Table 2 Hemagglutination-inhibition antibody responses after QIV in the per-protocol immunogenicity cohort
Strain | Time point | Seropositive | GMT | MGI | |||
|---|---|---|---|---|---|---|---|
n (%; 95% CI) | value (95% CI) | value (95% CI) | |||||
18–60 years | >60 years | 18–60 years | >60 years | 18–60 years | >60 years | ||
N = 56 | N = 56 | N = 56 | N = 56 | N = 56 | N = 56 | ||
A/H1N1 | Day 0 | 49 | 40 | 82.0 | 25.0 | – | – |
(87.5; 75.9–94.8) | (71.4; 57.8–82.7) | (54.9–122.5) | (17.3–36.0) | ||||
Day 21 | 56 | 55 | 392.5 | 223.5 | 4.8 | 8.9 | |
(100; 93.6–100) | (98.2; 90.4–100) | (305.4–504.4) | (157.0–318.1) | (3.3–7.0) | (5.8–13.7) | ||
A/H3N2 | Day 0 | 49 | 40 | 45.3 | 23.2 | – | – |
(87.5; 75.9–94.8) | (71.4; 57.8–82.7) | (31.3–65.4) | (16.4–32.8) | ||||
Day 21 | 56 | 55 | 215.4 | 160.1 | 4.8 | 6.9 | |
(100; 93.6–100) | (98.2; 90.4–100) | (166.3–278.9) | (115.7–221.4) | (3.5–6.6) | (4.7–10.1) | ||
B strain (Victoria) | Day 0 | 54 | 52 | 92.8 | 38.5 | – | – |
(96.4; 87.7–99.6) | (92.9; 82.7–98.0) | (66.5–129.4) | (28.3–52.4) | ||||
Day 21 | 56 | 56 | 318.0 | 237.8 | 3.4 | 6.2 | |
(100; 93.6–100) | (100; 93.6–100) | (251.4–402.3) | (179.7–314.9) | (2.5–4.6) | (4.3–8.8) | ||
B strain (Yamagata) | Day 0 | 56 | 54 | 130.4 | 57.3 | – | – |
(100; 93.6–100) | (96.4; 87.7–99.6) | (92.8–183.2) | (44.3–74.0) | ||||
Day 21 | 56 | 56 | 404.8 | 355.5 | 3.1 | 6.2 | |
(100; 93.6–100) | (100; 93.6–100) | (323.1–507.2) | (263.5–479.5) | (2.4–4.0) | (4.6–8.4) | ||