Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways

Frade, Amanda Farage; Pissetti, Cristina Wide; Ianni, Barbara Maria; Saba, Bruno; Lin-Wang, Hui Tzu; Nogueira, Luciana Gabriel; de Melo Borges, Ariana; Buck, Paula; Dias, Fabrício; Baron, Monique; Ferreira, Ludmila Rodrigues Pinto; Schmidt, Andre; Marin-Neto, José Antonio; Hirata, Mario; Sampaio, Marcelo; Fragata, Abílio; Pereira, Alexandre Costa; Donadi, Eduardo; Kalil, Jorge; Rodrigues, Virmondes; Cunha-Neto, Edecio; Chevillard, Christophe

doi:10.1186/1471-2334-13-587

Table 5 Genotype distribution on controls (ASY individuals) and cases (CCC) taking into account the gender and the left ventricular ejection fraction values

From: Genetic susceptibility to Chagas disease cardiomyopathy: involvement of several genes of the innate immunity and chemokine-dependent migration pathways

			ASY			CCC			CCC (EF ≤ 0.4)			CCC (EF ≥ 0.4)
Gene	SNP	Genotype	Total	Male	Female	Total	Male	Female	Total	Male	Female	Total	Male	Female
CCR5	rs3176763	CC	110	50	59	266	167	97	169	127	42	88	34	54
CCR5	rs3176763	CC	(94.0%)	(96.2%)	(92.2%)	(84.4%)	(87.0%)	(80.2%)	(84.9%)	(88.2%)	(76.4%)	(89.0%)	(81.0%)	(84.4%)
		CA	7	2	5	48	25	23	30	17	13	17	8	9
		CA	(6.0%)	(3.8%)	(7.8%)	(15.2%)	(13.0%)	(19.0%)	(15.1%)	(11.8%)	(23.6%)	(16.0%)	(19.0%)	(14.1%)
		AA	0	0	0	1	0	1	0	0	0	1	0	1
		AA	(0.0%)	(0.0%)	(0.0%)	(0.3%)	(0.0%)	(0.8%)	(0.0%)	(0.0%)	(0.0%)	(0.9%)	(0.0%)	(1.6%)
CCR5	rs3087253	AA	46	18	28	134	81	52	80	61	19	52	20	32
CCR5	rs3087253	AA	(41.4%)	(36.7%)	(45.9%)	(43.9%)	(43.5%)	(44.4%)	(41.0%)	(43.3%)	(35.2%)	(51.0%)	(50.0%)	(51.6%)
		AG	47	22	24	119	73	46	80	52	28	34	16	18
		AG	(42.3%)	(44.9%)	(39.3%)	(39.0%)	(39.2%)	(39.3%)	(41.0%)	(36.9%)	(51.9%)	(33.3%)	(40.0%)	(29.0%)
		GG	18	9	9	52	32	19	35	28	7	16	4	12
		GG	(16.2%)	(18.4%)	(14.8%)	(17.0%)	(17.2%)	(16.2%)	(17.9%)	(19.9%)	(13.0%)	(15.7%)	(10.0%)	(19.4%)
CCR5	rs11575815	AA	51	25	25	158	97	60	104	74	22	51	22	29
CCR5	rs11575815	AA	(45.1%)	(49.0%)	(41.0%)	(51.3%)	(51.6%)	(50.8%)	(52.8%)	(52.1%)	(53.7%)	(50.0%)	(53.7%)	(47.5%)
		AT	42	20	22	120	70	49	71	50	16	43	16	27
		AT	(37.2%)	(39.2%)	(36.1%)	(39.0%)	(37.2%)	(41.5%)	(36.0%)	(35.2%)	(39.0%)	(42.2%)	(39.0%)	(44.3%)
		TT	20	6	14	30	21	9	22	18	3	8	3	5
		TT	(17.7%)	(11.8%)	(23.0%)	(9.7%)	(11.2%)	(7.6%)	(11.2%)	(12.7%)	(7.3%)	(7.8%)	(7.3%)	(8.2%)
CCL2	rs3760396	GG	87	41	45	247	152	94	153	112	41	87	36	51
CCL2	rs3760396	GG	(75.7%)	(80.4%)	(71.4%)	(79.9%)	(80.9%)	(79.0%)	(77.7%)	(78.9%)	(74.5%)	(85.3%)	(90.0%)	(82.3%)
		GC	27	9	18	60	35	24	43	29	14	14	4	10
		GC	(23.5%)	(17.6%)	(28.6%)	(19.4%)	(18.6%)	(20.2%)	(21.8%)	(20.4%)	(25.5%)	(13.7%)	(10.0%)	(16.1%)
		CC	1	1	0	2	1	1	1	1	0	1	0	1
		CC	(0.9%)	(2.0%)	(0.0%)	(0.6%)	(0.5%)	(0.8%)	(0.5%)	(0.7%)	(0.0%)	(1.0%)	(0.0%)	(1.6%)
CCL2	rs2857656	CC	50	24	25	122	70	50	77	52	25	42	17	25
CCL2	rs2857656	CC	(44.2%)	(48.0%)	(40.3%)	(39.7%)	(37.6%)	(42.0%)	(39.3%)	(36.9%)	(45.5%)	(41.2%)	(42.5%)	(40.3%)
		CG	51	22	29	150	92	58	96	72	24	51	18	33
		CG	(45.1%)	(44.0%)	(46.8%)	(48.9%)	(49.5%)	(48.7%)	(49.0%)	(51.1%)	(43.6%)	(50.0%)	(45.0%)	(53.2%)
		GG	12	4	8	35	24	11	23	17	6	9	5	4
		GG	(10.6%)	(8.0%)	(12.9%)	(11.4%)	(12.9%)	(9.2%)	(11.7%)	(12.1%)	(10.9%)	(8.8%)	(12.5%)	(6.5%)
CCL2	rs4586	TT	38	20	18	74	41	32	46	31	15	26	9	17
CCL2	rs4586	TT	(34.5%)	(40.8%)	(30.0%)	(24.0%)	(21.7%)	(27.4%)	(23.4%)	(21.8%)	(27.3%)	(25.5%)	(22.0%)	(27.9%)
		TC	53	23	29	148	90	57	94	70	24	52	19	33
		TC	(48.2%)	(49.9%)	(48.3%)	(48.1%)	(47.6%)	(48.7%)	(47.7%)	(49.3%)	(43.6%)	(51.0%)	(46.3%)	(54.1%)
		CC	19	6	13	86	58	28	57	41	16	26	13	11
		CC	(17.3%)	(12.2%)	(21.7%)	(27.9%)	(30.7%)	(23.9%)	(28.9%)	(28.9%)	(29.1%)	(25.5%)	(31.7%)	(18.0%)
CCL2	rs3917891	CC	107	47	59	264	161	101	166	120	46	91	37	54
CCL2	rs3917891	CC	(93.9%)	(90.4%)	(96.7%)	(86.0%)	(86.1%)	(85.6%)	(85.6%)	(85.7%)	(85.2%)	(88.3%)	(90.2%)	(87.1%)
		CT	7	5	2	41	25	16	26	19	7	12	4	8
		CT	(6.1%)	(9.6%)	(3.3%)	(13.4%)	(13.4%)	(13.6%)	(13.4%)	(13.6%)	(13.0%)	(11.7%)	(9.9%)	(12.9%)
		TT	0	0	0	2	1	1	2	1	1	0	0	0
		TT	(0.0%)	(0.0%)	(0.0%)	(0.7%)	(0.5%)	(0.8%)	(1.0%)	(0.7%)	(1.9%)	(0.0%)	(0.0%)	(0.0%)
CCL2	rs2530797	AA	47	13	33	163	104	58	110	81	29	47	19	28
CCL2	rs2530797	AA	(41.6%)	(25.5%)	(54.1%)	(52.9%)	(55.6%)	(48.7%)	(55.8%)	(57.0%)	(52.7%)	(45.6%)	(47.5%)	(44.4%)
		AG	52	33	19	115	68	46	69	51	18	44	16	28
		AG	(46.0%)	(64.7%)	(31.1%)	(37.3%)	(36.4%)	(38.7%)	(35%)	(35.9%)	(32.7%)	(42.7%)	(40%)	(44.4%)
		GG	14	5	9	30	15	15	18	10	8	12	5	7
		GG	(12.4%)	(9.8%)	(14.8%)	(9.7%)	(8.0%)	(12.6%)	(9.1%)	(7.0%)	(14.5%)	(11.7%)	(12.5%)	(11.1%)
CCL2	rs991804	CC	51	25	25	120	67	51	78	52	26	40	15	25
CCL2	rs991804	CC	(45.5%)	(48.1%	(42.4%)	(41.2%)	(38.3%)	(44.7%)	(42.6%)	(39.4%)	(51.0%)	(40.4%)	(39.5%)	(41.0%)
		CT	53	24	29	148	92	56	88	67	21	54	20	34
		CT	(47.3%)	(46.2%)	(49.2%)	(50.9%)	(52.6%)	(51.1%)	(48.1%)	(50.8%)	(41.2%)	(54.5%)	(52.6%)	(55.7%)
		TT	8	3	5	23	16	7	17	13	4	5	3	2
		TT	(7.1%)	(5.8%)	(8.5%)	(7.9%)	(9.1%)	(6.1%)	(9.3%)	(9.8%)	(7.8%)	(5.1%)	(7.9%)	(3.3%)
TIRAP	rs11220437	TT	92	44	47	229	142	85	146	106	40	74	31	43
TIRAP	rs11220437	TT	(80.0%)	(84.6%)	(75.8%)	(73.9%)	(74.7%)	(72.0%)	(73.7%)	(73.6%)	(74.1%)	(71.8%)	(75.6%)	(69.4%)
		TC	22	8	14	76	45	31	48	36	12	28	9	19
		TC	(19.1%)	(15.4%)	(22.6%)	(24.5%)	(23.7%)	(26.3%)	(24.2%)	(25.0%)	(22.2%)	(27.2%)	(22.0%)	(30.6%)
		CC	1	0	1	5	3	2	4	2	2	1	1	0
		CC	(9.0%)	(0.0%)	(1.6%)	(1.6%)	(1.6%)	(1.7%)	(2.0%)	(1.4%)	(3.7%)	(1.0%)	(2.4%)	(0.0%)
TIRAP	rs591163	GG	51	23	28	158	95	82	104	74	20	52	30	32
TIRAP	rs591163	GG	(46.4%)	(46.9%)	(46.7%)	(51.5%)	(50.5%)	(53.0%)	(53.1%)	(52.1%)	(50.0%)	(51.5%)	(55.6%)	(52.5%)
		GA	44	19	24	120	76	43	75	56	16	38	19	22
		GA	(40.0%)	(38.8%)	(40.0%)	(39.1%)	(40.4%)	(36.8%)	(38.3%)	(39.4%)	(40.0%)	(37.6%)	(35.2%)	(36.1%)
		AA	15	7	8	29	17	12	17	12	4	11	5	7
		AA	(13.6%)	(14.3%)	(13.3%)	(9.4%)	(9.0%)	(10.3%)	(8.7%)	(8.5%)	(10.0%)	(10.9%)	(9.3%)	(11.5%)
TIRAP	rs8177352	AA	83	38	44	225	132	91	140	98	42	80	31	49
TIRAP	rs8177352	AA	(73.5%)	(4.5%)	(72.1%)	(73.3%)	(70.6%)	(77.1%)	(71.4%)	(69.5%)	(76.4%)	(77.7%)	(75.6%)	(79.0%)
		AG	28	12	16	73	48	25	47	36	11	23	10	13
		AG	(24.8%)	(23.5%)	(26.2%)	(23.8%)	(25.7%)	(21.2%)	(24.0%)	(25.5%)	(20.0%)	(22.3%)	(24.4%)	(21.0%)
		GG	2	60	1	9	7	2	9	7	2	0	0	0
		GG	(1.8%)	(23.5%)	(1.6%)	(2.9%)	(3.7%)	(1.7%)	(4.6%)	(5.0%)	(3.6%)	(0.0%)	(0.0%)	(0.0%)
TIRAP	rs8177375	AA	95	45	49	246	153	91	156	115	41	82	34	48
TIRAP	rs8177375	AA	(84.1%)	(88.2%)	(80.3%)	(79.4%)	(81.4%)	(75.8%)	(79.2%)	(81.0%)	(74.5%)	(78.8%)	(82.9%)	(76.2%)
		AG	16	5	11	60	33	27	39	26	13	20	6	14
		AG	(14.2%)	(9.8%)	(18.0%)	(19.4%)	(17.6%)	(22.5%)	(19.8%)	(18.3%)	(23.6%)	(19.2%)	(14.6%)	(22.2%)
		GG	2	1	1	4	2	2	2	1	1	2	1	1
		GG	(1.8%)	(2.0%)	(1.6%)	(1.2%)	(1.0%)	(1.7%)	(1.0%)	(0.7%)	(1.8%)	(1.9%)	(2.4%)	(1.6%)
TIRAP	rs8177376	AA	63	26	37	230	143	85	149	110	39	74	29	45
TIRAP	rs8177376	AA	(54.9%)	(57.8%)	(60.7%)	(75.4%)	(77.7%)	(71.4%)	(76.8%)	(79.1%)	(70.9%)	(71.8%)	(72.5%)	(71.4%)
		AC	40	18	22	70	40	30	44	28	16	25	11	14
		AC	(37.7%)	(40.0%)	(36.1%)	(23.0%)	(21.7%)	(25.2%)	(22.7%)	(20.1%)	(29.1%)	(24.3%)	(27.5%)	(22.2%)
		CC	3	1	2	5	1	4	1	1	0	4	0	4
		CC	(2.8%)	(2.2%)	(3.3%)	(1.6%)	(0.5%)	(3.4%)	(0.5%)	(0.7%)	(0.0%)	(3.9%)	(0.0%)	(6.3%)
TIRAP	rs17866704	TT	80	35	44	175	103	71	115	80	35	54	20	34
TIRAP	rs17866704	TT	(70.8%)	(70.0%)	(71.0%)	(57.4%)	(55.4%)	(60.7%)	(59.0%)	(56.7%)	(64.8%)	(53.5%)	(50.0%)	(55.7%)
		TC	32	15	17	106	64	41	63	46	17	40	16	24
		TC	(28.3%)	(30.0%)	(27.4%)	(34.8%)	(34.4%)	(35.0%)	(32.3%)	(32.6%)	(31.5%)	(39.6%)	(40%)	(39.3%)
		CC	1	0	1	24	19	5	17	15	2	7	4	3
		CC	(0.9%)	(0.0%)	(1.6%)	(7.9%)	(10.2%)	(4.3%)	(8.7%)	(10.6%)	(3.7%)	(6.9%)	(10.0%)	(4.9%)

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