Table 1 Results on hospitalized RVGE cases, costs and QALYs for the original study and with new hospitalization data and herd protection
No vaccination | Vaccination | Difference | ||||
|---|---|---|---|---|---|---|
Individuals aged <5y | Individuals aged ≥5y | Individuals aged <5y | Individuals aged ≥5y | Individuals aged <5y | Individuals aged ≥5y | |
Number of hospitalized cases from the original study 1 | ||||||
Community accquired | 2,817 | 161 | 353 | 161 | 2,464 | 0 |
Nosocomial | 421 | 149 | 106 | 149 | 315 | 0 |
Number of hospitalized cases from the original study (including herd protection for children <5 years) | ||||||
Community accquired | 2,817 | 161 | 155 | 161 | 2,662 | 0 |
Nosocomial | 421 | 149 | 23 | 149 | 398 | 0 |
Number of hospitalized cases using the updated hospitalization data (and herd protection for <5 years) 2 | ||||||
Community accquired | 4,241 | 223 | 233 | 223 | 4,008 | 0 |
Nosocomial | 634 | 207 | 35 | 207 | 599 | 0 |
Number of hospitalized cases using the updated hospitalization data and herd protection (for <25 years) 2 | ||||||
Community accquired | 4,241 | 223 | 233 | 180 | 4,008 | 43 |
Nosocomial | 634 | 207 | 35 | 167 | 599 | 40 |
Discounted cost and QALYs from the original study 1 | ||||||
Total costs (direct and indirect)3 | 9,663,000 | 6,519,000 | 2,074,000 | 6,519,000 | 7,589,000 | 0 |
Total QALYs | 173 | NA4 | 64 | NA4 | 109 | NA4 |
Discounted cost and QALYs from the original study (including herd protection for <5 years only) | ||||||
Total costs (direct and indirect)3 | €9,663,000 | €6,519,000 | €969,000 | €6,519,000 | €8,694,000 | €0 |
Total QALYs | 173 | NA4 | 32 | NA4 | 141 | NA4 |
Discounted cost and QALYs using the updated hospitalization data (and herd protection <5 years) 2 | ||||||
Total costs (direct and indirect)3 | €13,246,000 | €6,937,000 | €1,203,000 | €6,937,000 | €12,043,000 | €0 |
Total QALYs | 207 | NA4 | 37 | NA4 | 170 | NA4 |
Discounted costs and QALYs using updated hospitalization data and herd protection (for <25) 2 | ||||||
Total costs (direct and indirect costs)3 | €13,246,000 | €6,937,000 | €1,203,000 | €6,833,000 | €12,043,000 | €104,000 |
Total QALYs | 207 | NA4 | 37 | NA4 | 170 | NA4 |