Selected SNP | Genotype distribution* | p for difference | |||
---|---|---|---|---|---|
Gene | SNP (ID) | PTB patients, n (%) | LTBI controls n (%) | Healthy controls without MTB infection n (%) | |
CCR2 | GG | 125 (62.5) | 125 (63.5) | 120 (61.2) | 0.397§ |
190 A/G | GA | 62 (31.0) | 65 (33.0) | 67 (34.2) | 0.612& |
(rs1799864) | AA | 13 (6.5) | 7 (3.6) | 9 (4.6) | |
CCR5 | GG | 71 (35.5) | 62 (31.5) | 59 (30.1) | 0.511§ |
59029 A/G | GA | 97 (48.5) | 107 (54.3) | 102 (52.0) | 0.515& |
(rs1799987) | AA | 32 (16.0) | 28 (14.2) | 35 (17.9) | |
RANTES | GG | 77 (38.5) | 63 (32.0) | 74 (37.8) | 0.349§ |
-403 G/A | GA | 96 (48.0) | 101 (51.3) | 95 (48.5) | 0.988& |
(rs2107538) | AA | 27 (13.5) | 33 (16.8) | 27 (13.8) | |
MCP1 | GG | 71 (35.5) | 64 (32.5) | 75 (38.3) | 0.632§ |
2518 A/G | GA | 96 (48.0) | 104 (52.8) | 88 (44.9) | 0.812& |
(rs1024611) | AA | 33 (16.5) | 29 (14.7) | 33 (16.8) | |
NRAMP1 | GG | 151 (75.5) | 151 (76.7) | 139 (70.9) | 0.837§ |
D543N | GA | 47 (23.5) | 43 (21.8) | 55 (28.1) | 0.582& |
(rs17235409) | AA | 2 (1.0) | 3 (1.5) | 2 (1.0) | |
P2X7 | AA | 116 (58.0) | 113 (57.4) | 109 (55.6) | 0.502§ |
1513 A/C | AC | 76 (38.0) | 71 (36.0) | 76 (38.8) | 0.722& |
(rs3751143) | CC | 8 (4.0) | 13 (6.6) | 11 (5.6) | |
P2X7 | CC | 92 (46.2) | 86 (43.7) | 86 (43.9) | 0.835§ |
-762 T/C | CT | 81 (40.7) | 86 (43.7) | 88 (44.9) | 0.669& |
(rs2393799) | TT | 26 (13.1) | 25 (12.7) | 22 (11.2) | |
TNF-α | GG | 169 (84.5) | 178 (90.4) | 176 (89.8) | 0.210§ |
-308 G/A | GA | 29 (14.5) | 18 (9.1) | 19 (9.7) | 0.284& |
(rs1800629) | AA | =2 (1.0) | 1 (0.5) | 1 (0.5) | |
IFNG | AA | 74 (37.0) | 57 (28.9) | 73 (37.2) | 0.119§ |
2109 G/A | AG | 97 (48.5) | 99 (50.3) | 85 (43.4) | 0.374& |
(rs1861494) | GG | 29 (14.5) | 41 (20.8) | 38 (19.4) | |
CD4 | CC | 188 (94.0) | 185 (93.9) | 184 (93.9) | 0.593§ |
868 C/T | CT | 11 (5.5) | 12 (6.1) | 12 (6.1) | 0.593& |
(rs28919570) | TT | 1 (0.5) | 0 | 0 | |
CD14 | TT | 54 (27.1) | 66 (33.5) | 60 (30.6) | 0.331§ |
159 C/T | TC | 103 (51.7) | 97 (49.2) | 104 (53.1) | 0.438& |
(rs2569190) | CC | 42 (21.1) | 34 (17.3) | 32 (16.3) | |
MBL | CC | 150 (75.0) | 150 (76.1) | 141 (71.9) | 0.964§ |
-221 G/C | CG | 48 (24.0) | 45 (22.8) | 52 (26.5) | 0.742& |
(rs7096206) | GG | 2 (1.0) | 2 (1.0) | 3 (1.5) | |
TIRAP | CC | 196 (98.0) | 190 (96.5) | 188 (96.4) | 0.346§ |
539 C/T | CT | 4 (2.0) | 7 (3.6) | 7 (3.6) | 0.359& |
(rs8177374) | TT | 0 | 0 | 0 | |
NFKBIA | AA | 150 (75.0) | 148 (75.1) | 153 (78.1) | 0.999§ |
-881 A/G | AC | 48 (24.0) | 47 (23.8) | 43 (21.9) | 0.322& |
(rs3138053) | CC | 2 (1.0) | 2 (1.0) | 0 | |
NFKBIA | CC | 149 (74.9) | 148 (75.1) | 153 (78.1) | 0.998§ |
-826 C/T | CT | 48 (24.1) | 47 (23.8) | 43 (21.9) | 0.316& |
(rs2233406) | TT | 2 (1.0) | 2 (1.0) | 0 |