Association between tuberculin skin test result and clinical presentation of tuberculosis disease

BMC Infectious Diseases

Table 2 Multinomial associations between clinical presentation of disease and tuberculin skin test (TST) result stratified by HIV status and birthplace and adjusted for age and sex among selected culture confirmed TB cases reported in the United States, 1993–2010 (N = 64,238)

		Miliary disease		Pulmonary & Extrapulmonary disease		Extrapulmonary only disease		Cavitary pulmonary disease
		aOR*	95% CI*	aOR	95% CI	aOR	95% CI	aOR	95% CI
HIV+/US
	0–4 mm	Ref		Ref		Ref
	5–9 mm	0.96	0.47, 1.95	0.72	0.42, 1.22	1.29	0.81, 2.06	1.11	0.64, 1.94
	10–14 mm	0.72	0.51, 1.01	0.81	0.65, 1.01	1.23	1.00, 1.53	1.36	1.07, 1.72
	≥ 15 mm	0.50	0.37, 0.68	0.86	0.72, 1.03	1.09	0.91, 1.31	1.56	1.29, 1.90
HIV+/FB
	0–4 mm	Ref		Ref		Ref		Ref
	5–9 mm	0.18	0.02, 1.29	0.93	0.49, 1.79	1.01	0.53, 1.94	1.68	0.75, 3.75
	10–14 mm	0.66	0.42, 1.04	0.80	0.60, 1.08	0.96	0.71, 1.28	1.85	1.27, 2.69
	≥ 15 mm	0.59	0.40, 0.86	0.65	0.50, 0.84	1.16	0.92, 1.47	2.20	1.60, 3.02
HIV-/US
	0–4 mm	Ref		Ref		Ref		Ref
	5–9 mm	0.77	0.43, 1.38	1.09	0.78, 1.52	1.05	0.79, 1.39	1.32	1.11, 1.56
	10–14 mm	0.49	0.37, 0.66	0.77	0.64, 0.91	1.05	0.92, 1.20	1.09	1.00, 1.18
	≥ 15 mm	0.41	0.32, 0.53	0.80	0.70, 0.93	1.11	0.99, 1.24	1.11	1.03, 1.20
HIV-/FB
	0–4 mm	Ref		Ref		Ref		Ref
	5–9 mm	0.56	0.34, 0.93	0.61	0.43, 0.86	0.82	0.63, 1.06	0.84	0.69, 1.04
	10–14 mm	0.22	0.16, 0.30	0.51	0.42, 0.62	0.85	0.74, 0.99	0.92	0.82, 1.03
	≥ 15 mm	0.19	0.15, 0.25	0.56	0.48, 0.67	1.03	0.90, 1.17	0.81	0.73, 0.90

Non-cavitary pulmonary disease, with the largest number of cases, is the referent clinical category and 0–4 mm (negative) is the referent TST category for all comparisons.
*aOR adjusted odds ratio, 95% CI 95% Confidence Interval.
Note: Numbers in bold represent significant 95% confidence intervals.

ISSN: 1471-2334