Figure 1

Survival curves of mice infected with S. pneumoniae strains. A. MF1 mice were infected by the i.c. route with 10², 10³ and 10⁴ cfu/mouse of TIGR4 (wt, open squares), FP28 (PspC-, closed circles) and FP262 (PspA-, closed triangles). As a control, animals were also inoculated with different doses (10²-10⁷ cfu/mouse) of the unencapsulated mutant FP23 (open circles). Percent survival at different doses is shown. Data of two independent experiments are combined. B. Kaplan-Meyer curve of mouse survival following infection with 10² cfu/mouse of TIGR4, FP28, FP262 and FP23. Mice were monitored for 10 days. Asterisks indicate statistical significance (**, p < 0.001; Log Rank test).