Table 2 Univariable and multivariable odds ratios for cardiovascular events according to biomarkers in late samples
Biomarkers | Unadjusted OR (95% CI) | p-value | Adjusted*OR (95% CI) | p-value |
|---|---|---|---|---|
(a)Biomarkers as categorical variables | ||||
t-PA, ng/ml | ||||
<=8.7 (n=27) | 1.00 | 1.00 | ||
8.7-14.8 (n=26) | 1.56 (0.48, 5.10) | 0.459 | 2.54 (0.52, 12.31) | 0.247 |
>14.8 (n=35) | 0.99 (0.31, 3.14) | 0.989 | 0.35 (0.05, 2.31) | 0.278 |
Not measured (n=16) | 2.99 (0.81, 10.95) | 0.099 | 4.06 (0.50, 32.74) | 0.188 |
PAI-1, ng/ml | ||||
<=112 (n=36) | 1.00 | 1.00 | ||
112-207 (n=27) | 1.15 (0.33, 3.96) | 0.828 | 0.55 (0.11, 2.74) | 0.468 |
>207 (n=29) | 2.99 (0.98, 9.12) | 0.054 | 3.20 (0.75, 13.76) | 0.118 |
Not measured (n=12) | 3.62 (0.91, 14.49) | 0.069 | 3.02 (0.23, 39.02) | 0.397 |
D-dimer, ng/ml | ||||
<=67 (n=18) | 1.00 | 1.00 | ||
67-125 (n=27) | 0.55 (0.15, 2.10) | 0.384 | 0.32 (0.06, 1.84) | 0.202 |
>125 (n=28) | 0.72 (0.20, 2.61) | 0.617 | 0.63 (0.12, 3.28) | 0.585 |
Not measured (n=31) | 1.70 (0.51, 5.62) | 0.387 | 0.55 (0.10, 2.90) | 0.482 |
hsCRP, mg/L | ||||
< 0.9 (n=28) | 1.00 | 1.00 | ||
0.9-3.3 (n=31) | 1.59 (0.46, 5.55) | 0.467 | 5.25 (0.56, 49.67) | 0.148 |
>3.3 (n=28) | 4.28 (1.28, 14.36) | 0.019 | 10.71 (1.03, 111.0) | 0.047 |
Not measured (n=17) | 2.54 (0.64, 10.11) | 0.187 | 3.88 (0.23, 66.29) | 0.349 |
IL-6, pg/ml | ||||
< 0.3 (n=20) | 1.00 | 1.00 | ||
0.3-1.9 (n=34) | 0.67 (0.20, 2.31) | 0.529 | 0.13 (0.02, 0.86) | 0.034 |
>1.9 (n=37) | 1.39 (0.43, 4.46) | 0.580 | 0.36 (0.06, 2.05) | 0.249 |
Not measured (n=13) | 2.03 (0.48, 8.50) | 0.334 | 0.64 (0.04, 9.07) | 0.738 |
P-selectin, ng/ml | ||||
< 157 (n=38) | 1.00 | 1.00 | ||
157-236 (n=28) | 1.23 (0.36, 4.19) | 0.744 | 1.40 (0.29, 6.87) | 0.676 |
>236 (n=25) | 4.39 (1.43, 13.45) | 0.010 | 3.94 (0.82, 18.88) | 0.086 |
Not measured (n=13) | 3.41 (0.88, 13.20) | 0.075 | 2.84 (0.24, 33.51) | 0.407 |
(b)Biomarkers as continuous variables (Log Scale) | ||||
t-PA, ng/ml | ||||
Per log2 higher | 0.97 (0.55, 1.74) | 0.926 | 0.78 (0.35, 1.76) | 0.554 |
PAI-1, ng/ml | ||||
Per log2 higher | 1.47 (0.96, 2.24) | 0.073 | 1.40 (0.81, 2.42) | 0.233 |
D-dimer, ng/ml | ||||
Per log2 higher | 0.89 (0.57, 1.41) | 0.626 | 0.97 (0.55, 1.72) | 0.918 |
hsCRP, mg/L | ||||
Per log2 higher | 1.61 (1.18, 2.18) | 0.002 | 1.69 (1.09, 2.64) | 0.020 |
IL-6, pg/ml | ||||
Per log2 higher | 1.09 (0.81, 1.45) | 0.568 | 1.05 (0.72, 1.53) | 0.799 |
P-selectin, ng/ml | ||||
Per log2 higher | 2.88 (1.38, 6.02) | 0.005 | 3.14 (1.04, 9.45) | 0.042 |