Lymphatic filariasis control in Tanzania: effect of six rounds of mass drug administration with ivermectin and albendazole on infection and transmission

Table 1 Timing of mass drug administration (MDA) and major village and school survey activities

MDA	Village surveys	School surveys
	Sep-04: Survey 1, in hamlets 1, 2, 3 and 4 (mf, clin, Og4C3, Bm14)	Sep-04: Survey 1 (ICT)
Oct-04: MDA1
	Jan-06: Survey 2, in hamlets 1, 2, 3 and 4 (mf, Og4C3, Bm14)	Sep-05: Survey 2 (ICT)
Feb-06: MDA2
	Jan-07: Survey 3, in hamlets 1, 2, 3 and 4 (mf, Og4C3, Bm14)	Oct-06: Survey 3 (ICT)
May-07: MDA3
	Oct-07: Survey 4, in hamlets 1, 2, 3 and 4 (mf, Og4C3, Bm14)	Oct-07: Survey 4 (ICT)
	Oct-08: Survey 5, in hamlets 1, 2, 3 and 4 (mf, Og4C3, Bm14)	Oct-08: Survey 5 (ICT)
Feb-09: MDA4
	Oct-09: Survey 6, in hamlets 1, 2, 3 and 4 (mf)	Oct-09: Survey 6 (ICT)
Nov-09: MDA5
	Nov-10: Survey 7, in hamlets 1, 2, 5 and 6 (ICT, mf)	Nov-10: Survey 7 (ICT, Bm14)
Dec-10: MDA6
	Nov-11: Survey 8, in hamlets 1, 2, 5 and 6 (ICT, mf, Bm14)	Dec-11: Survey 8 (ICT, Bm14)

Hamlets 1, 2, 3 and 4 were in Kirare village, hamlet 5 in Kiomoni village and hamlet 6 in Kisimatui village. Types of examinations: mf = microfilariae; clin = chronic clinical manifestations; Og4C3 = circulating filarial antigens by TropBio Og4C3 ELISA; ICT = circulating filarial antigens by ICT cards; Bm14 = antibodies to recombinant Bm14 antigen (by in-house ELISA during village surveys 1-5; by CELISA from Cellabs during surveys 7 and 8). In addition to listed activities, entomological surveillance was carried out in Kirare village continuously, and questionnaire surveys for MDA coverage was carried out in all communities and schools shortly after each MDA (the post-MDA 5 and 6 questionnaires in communities also assessed for possession of bed nets). A population census covering hamlets included in subsequent surveys was done in 2004 (before Survey 1) and 2010 (before Survey 7). Impregnated bed nets were distributed to every household in the study area in September 2011.

ISSN: 1471-2334