Table 2 Diagnostic criteria and 28S-ITS2 qPCR results for invasive aspergillosis
Diagnostic criteria | IA category | Total (%) (n=41) | ||
|---|---|---|---|---|
| Â | Proven (%) (n=4) | Probable (%) (n=18) | Possible (%) (n=19) | Â |
Host factors | Â | Â | Â | Â |
  Neutropenia | 4 (100) | 6 (33.3) | 3 (15.8) | 13 (31.7) |
  T > 38°C with |  |  |  |  |
  Prolonged neutropenia | 4 (100) | 11 (61.1) | 6 (31.6) | 21 (51.2) |
  Immunosuppressant | 1 (25) | 9 (50) | 9 (47.4) | 19 (46.3) |
  Previous IFI | 0 (0) | 4 (22.2) | 3 (15.8) | 7 (17.1) |
  With AIDS | 0 (0) | 0 (0) | 0 (0) | 0 (0) |
  GVHD | 0 (0) | 3 (16.7) | 2 (10.5) | 5 (12.2) |
  Corticosteroids | 3 (75) | 4 (22.2) | 7 (36.8) | 14 (34.1) |
Clinical criteria | Â | Â | Â | Â |
  Halo sign | 3 (75) | 17 (94.4) | 12 (63.1) | 32 (78) |
  Air-crescent sign | 2 (50) | 1 (5.6) | 2 (10.5) | 5 (12.2) |
  Cavity | 1 (25) | 3 (16.7) | 0 (0) | 4 (9.8) |
  Symptoms of LRI | 3 (75) | 8 (44.4) | 13 (68.4) | 24 (58.5) |
  Permanent fever | 2 (50) | 7 (38.9) | 13 (68.4) | 22 (53.7) |
Mycological criteria | Â | Â | Â | Â |
  Positive sputum microscopy | 0(0) | 6 (33.3) | 0 (0) | 6 (14.6) |
  Positive sputum culture | 1 (25) | 5 (27.8) | 0 (0) | 6 (14.6) |
  G test positive | 1 (25) | 8 (44.4) | 1 (5.3) | 10 (24.4) |
  No bacterial positive | 0 (0) | 6 (33.3) | 3 (15.8) | 9 (22) |
Histology | Â | Â | Â | Â |
  Biopsy specimen of the lung | 4 (100) | 0 (0) | 0 (0) | 4 (9.8) |
qPCR results (copies/μL) (median, range) | 123.47 | 43.65 | 16.15 | 28.12 |
|  | (25.96–266.95) | (0–549.5) | (0–98.76) | (0–549.5) |