Figure 1

Association of CRT with CD4 absolute count over time (a) and HIV cumulative viremia (b). Legend: x axis (time) = years; y axis: a): CD4 = n/mmc, b): cumulative viremia = HIV-RNA log10 copy/years. The graph represents mean CD4 and HIV viral load (and standard errors) over time for R5 and X4 groups, predicted from multivariate mixed models including patient as “clustering” variable and time from first HIV testing (with quarters as unit of analysis), adjusting for baseline values (see Statistical methods). The red dashed line (Figure 1b) indicates the level of HIV RNA <500 copies/ml (2,69 log).