Table 6 Information on percentage of donors, and their T cell response and DRB MHC type of donors responding to predicted and conserved T cell epitopes
HA epitope and position | % donors responding to each epitope (responded donors/total donor | Total responding T cells | Mean number of responding T cells | DRB1 alleles of donors | Alleles of other DR haplotypes of donors |
|---|---|---|---|---|---|
STVASSLVLLVSLGA | 85 (12/14) | 376.5 | 31.4 | DRB1*03, DRB1*04, | DRB3*52, |
(518–532) | DRB1*07, DRB1*08, | DRB4*53, | |||
DRB1*13, DRB1*14, | DRB5*51 | ||||
DRB1*15, DRB1*17 | |||||
GAISFWMCSNGSLQC | 71 (9/14) | 243.5 | 27.1 | DRB1*03, DRB1*04, | DRB3*52, |
(531–545) | DRB1*07, DRB1*08, | DRB4*53, | |||
DRB1*13, DRB1*15, | DRB5*51 | ||||
DRB1*17 | |||||
YQILAIYSTVASSLV | 43 (6/14) | 144.5 | 24.1 | DRB1*04, DRB1*07, | DRB3*52, |
(511–525) | DRB1*08, DRB1*13, | DRB4*53, | |||
DRB1*15, DRB1*17 | DRB5*51 | ||||
IYQILAIYSTVASSL | 36 (5/14) | 73.5 | 14.7 | DRB1*07, DRB1*08, | DRB3*52, |
(510–524) | DRB1*13, DRB1*15, | DRB4*53, | |||
DRB1*17 | DRB5*51 | ||||
NKVNSVIEKMNTQFT | 29 (4/14) | 66.0 | 16.5 | DRB1*04, DRB1*07, | DRB3*52, |
(377–391) | DRB1*08, DRB1*13, | DRB4*53, | |||
DRB1*15, DRB1*17 | DRB5*51 | ||||
RNIPSIQSRGLFGAI | 29 (4/14) | 38.0 | 12.7 | DRB1*03, DRB1*04, | DRB3*52, |
(319–333) | DRB1*07, DRB1*13, | DRB4*53 | |||
DRB1*17 | |||||
LVLLENERTLDYHDS | 21 (3/14) | 33.0 | 11.0 | DRB1*07,DRB1*13, | DRB3*52, |
(426–440) | DRB1*17 | DRB4*53 | |||
YNAELLVLLENERTL | 21 (3/14) | 58.0 | 19.3 | DRB1*07,DRB1*13, | DRB3*52, |
(421–435) | DRB1*17 | DRB4*53 | |||
ATGLRNIPSIQSRGL | 21 (3/14) | 45.5 | 15.2 | DRB1*04, DRB1*07, | DRB3*52, |
(315–329) | DRB1*13, DRB1*17 | DRB4*53 | |||
DGFLDIWTYNAELLV | 14 (2/14) | 25.5 | 12.8 | DRB1*03, DRB1*07, | DRB3*52, |
(413–427) | DRB1*13, | DRB4*53 | |||
QLSSVSSFERFEIFP | 14 (2/14) | 25.5 | 12.8 | DRB1*04, DRB1*07, | DRB3*52, |
(104–119) | DRB1*13 | DRB4*53 | |||
VLEKNVTVTHSVNLL | 7 (1/14) | 11.5 | 11.5 | DRB1*04 | DRB3*52, |
(19–33) | DRB4*53 | ||||
EELREQLSSVSSFER | No response | - | - | - | - |
(99–113) |