Table 2 Management of patients with severe CAP
Historical | Intervention | ||
|---|---|---|---|
Group | Group | p | |
n=142 (44.8) | n=175 (55.2) | ||
NIMV within 48 hrs of admission, n (%) | 26 (18.3) | 35 (20) | 0.7 |
MV within 48 hrs of admission, n (%) | 106 (74.6) | 127 (72.6) | 0.18 |
Fluid administration within 24 hours of admission, ml | 1300 ± 1900 | 2200 ± 1700 | < 0.0001 |
Vasoactive drugs within 48 hrs of admission, n (%) | 74 (52.2) | 109 (62.3) | 0.07 |
Dobutamine, n (%) | 46 (32.4) | 17 (9.7) | < 0.0001 |
Dopamine, n (%) | 8 (5.6) | 10 (5.7) | 0.97 |
Norepinephrine, n (%) | 19 (13.4) | 105 (57.7) | < 0.0001 |
Epinephrine, n (%) | 20 (14.1) | 11 (6.3) | 0.02 |
Dual therapy, n (%) | 121 (85.2) | 158 (90.3) | 0.16 |
Adequate antimicrobial therapy/ documented pneumonia, n (%) | 82 (96.4) | 92 (92) | 0.20 |
Antimicrobial therapy within 8 h of admission, n (%) | 109 ( 76.7) | 138 (78.8) | 0.65 |
Combination of a 3rdGC and levofloxacin, n (%) | 0 | 115 (65.7) | < 0.0001 |
Insulin therapy, n (%) | 19 (13.4) | 151 (86.3) | |
Intensive insulin therapy, n (%) | 0 | 151 (86.3) | < 0.0001 |
Mean tidal volume, mL/kg | 8.17 ± 1.19 | 6.64 ± 0.73 | < 0.0001 |
Low-dose steroid administration, n (%) | 0 | 89 (50.8) | < 0.0001 |
Transfusion, n (%) | 62 (43.7) | 40 (22.8) | < 0.0001 |
Number of red blood cell units transfused per patient | 2.6 ± 4.5 | 0.8 ± 2.1 | < 0.0001 |
Systematic postextubation NIMV, n (%) | 8 (5.6) | 20 (11.4) | 0.07 |