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Table 3 Publications included in the cost-effectiveness review (n = 29)

From: Infection with hepatitis B and C virus in Europe: a systematic review of prevalence and cost-effectiveness of screening

First Author, year, reference

Target group

Setting

Country

Infection

Model

Data

Indicator^

Result*

Year of monetary value #

Euro in 2010

Cost-effective?

Thomas, 1990 [58]

Pregnant women

Antenatal care

Australia

HBV

None

Actual screening

Cost per case detected

$354 (AU)

1988

€ 379

Yes

Audet, 1991 [57]

Pregnant women

Antenatal care

Canada

HBV

None

Hypothetical cohort

Cost per case detected/infant carrier prevented

$1.693/$8.915 (CA)

1988

€ 1.799-€9.475

Yes, probably

Tormans, 1993 [54]

Pregnant women

Antenatal care

Belgium

HBV

Markov

Hypothetical cohort

Cost per LY gained

BEF 583.581

1991

€ 22.095

Yes

Dwyer, 1996 [56]

Pregnant women

Antenatal care

UK

HBV

Markov

Hypothetical cohort

Cost per carrier prevented/LY gained

£2.437/£16.450

Not mentioned (1996)

€ 3.879 -€26.181

Yes

Jordan, 1997 [55]

Pregnant women

Antenatal care

Britain

HBV

Markov

Hypothetical cohort

Cost per LY gained

₤1.300

Not mentioned (1997)

€ 2.032

Yes

Plunkett, 2005 [59]

Pregnant women

Antenatal care

USA

HCV

Markov

Hypothetical cohort

Cost per QALY

No screening dominant

2003

n.a.

No

Eckman, 2011 [47]

General population (35 year old males)

Primary care

USA

HBV

Markov

Hypothetical cohort

Cost per QALY

$29.232 (US)

2008

€ 23.966

Yes

Singer, 2001 [49]

General population

Not specified

USA

HCV

Markov

Hypothetical cohort

Cost per QALY

No screening dominant

2001

n.a.

No

Nakamura, 2008 [50]

General population & risk groups

Not specified

Japan

HCV

Markov

Actual screening

Cost per LY gained

$848 - $4.825 (US)

2007

€ 726-€4.130

Yes

Loubiere, 2003 [48]

General population, IDUs & other risk groups

Not specified

France

HCV

Markov

Hypothetical cohort

Cost per LY gained

$4.513 (US) (IDUs)/$5.821 (gen pop)

1998

€ 4.856/€6.263

Yes

Coffin, 2012 [51]

General population (20–69 y.o. and 1945–1965)

Not specified

USA

HCV

Markov

Hypothetical cohort

Cost per QALY

$7.900-$5.400 (US)

2010

€ 6.376-€4.358

Yes

McGarry, 2012 [52]

General population (born 1946–1970)

Not specified

USA

HCV

Markov

Hypothetical cohort

Cost per QALY

$37.720 (US)

2010

€ 30.444

Yes

Rein, 2012 [53]

General population (born 1945–1965)

Not specified

USA

HCV

Markov

Hypothetical cohort

Cost per QALY

$15.700 (US)

2009

€ 12.976

Yes

Ruggeri, 2011 [73]

High risk groups

Not specified

Italy

HBV

Markov

Hypothetical cohort

Cost per QALY

€18.255 (IT)

2004

€ 52.885

Yes

Hutton, 2007 [67]

Migrants

Not specified

USA

HBV

Markov

Hypothetical cohort

Cost per QALY

$36.088 (US)

2006

€ 31.692

Yes

Veldhuijzen, 2010 [68]

Migrants

Population based

Netherlands

HBV

Markov

Hypothetical cohort

Cost per QALY

€8.966 (Nl)

2009

€ 8.694

Yes

Rein, 2011 [69]

Migrants

5 settings compared

USA

HBV

None

Actual screening

Cost per case detected

$609-$4.657 (US)

2008

€499-€3.818

Yes

Wong, 2011 [70]

Migrants

Not specified

Canada

HBV

Markov

Hypothetical cohort

Cost per QALY

$69.209 (CA)

2008

€46.260

Yes, moderately

Leal, 1999 [60]

IDUs

Drug services

UK

HCV

Markov

Hypothetical cohort

Cost per QALY

£9.300

1997

€ 14.540

Yes

Castelnuovo, 2006 [61]

IDUs

Various

UK

HCV

Markov

Hypothetical cohort

Cost per QALY

£15.493-£20.083

2004

€ 22.172-€28.741

Yes

Thompson Coon, 2006 [62]

IDUs

Primary care

UK

HCV

Markov

Hypothetical cohort

Cost per QALY

£16.493

2002/2003

€ 24.245

Yes

Kerr, 2009 [43]

IDUs & MSM

STD clinic

Scotland

HCV

None

Actual screening

Cost per case detected

£ 170 (IDU)/£15.000 (MSM)

Not mentioned (2009)

€ 215-€18.975

Yes (IDU), No (MSM)

Josset, 2004 [63]

IDUs & other risk groups

Primary care

France

HCV

None

Actual screening

Cost per case detected

not reported

Not mentioned

n.a.

Not stated

Stein, 2004 [44]

IDUs & other risk groups

STD clinic/drug services

UK

HCV

Markov

Hypothetical cohort

Cost per QALY

₤28.120 (IDUs)/₤84.570 (GUM)

2001

€ 41.874-€125.933

Yes (IDUs)/No (GUM)

Honeycutt, 2007 [64]

IDUs & other risk groups

STD clinic

USA

HCV

None

Hypothetical cohort

Cost per case detected

$54 (US)

2006

€ 47

Yes

Tramarin, 2008 [65]

IDUs & other risk groups

Not specified

Italy

HCV

Markov

Hypothetical cohort

Cost per QALY

-€3.132 (IT)

2007

-€ 3.328

Yes

Helsper, 2012 [66]

IDUs & other risk groups incl migrants

Primary care/drug services

Netherlands

HCV

Markov

Actual screening

Cost per QALY

€7.321 (NL)

2007

€ 7.327

Yes

Sutton, 2006 [71]

Prisoners

Prison

UK

HCV

Markov

Hypothetical cohort

Cost per case detected

£2,102 - £3,107

2004

€ 3.008-€4.446

Yes

Sutton, 2008 [72]

Prisoners

Prison

UK

HCV

Markov

Hypothetical cohort

Cost per QALY

£54.852

2004

€ 78.498

No

  1. * Results of most favorable scenario reported here.
  2. # Where the paper did not quote year of monetary value the year of publication was used to convert the results into 2010 Euros [34].
  3. n.a. Not available.
  4. ^ QALY, Quality adjusted life year; LY, Life year.