Year | 2005 | 2006 | 2007 | 2008 | 2009 | P § | p-value trend # |  |
Patient (n) | 38 | 31 | 27 | 27 | 18 | Â | Â | Â |
Gender (m/f) | 20/18 | 16/15 | 14/13 | 18/9 | 11/7 | 0.728 | 0.289 | Â |
Age (years)* | 68.6 ±15.9 | 73.8 ±9.5 | 68.0 ±13.5 | 67.5 ±13.9 | 65.4 ±11.6 | 0.196 | 0.125 |  |
SAPS II * | 45.0 ±17.7 | 43.4 ±17.9 | 42.5 ±19.8 | 44.3 ±19.0 | 37.0 ±10.9 | 0.603 | 0.177 |  |
Apache II * | 20.0 ±8.8 | 20.5 ±8.8 | 18.2 ±8.7 | 17.9 ±9.7 | 15.6 ±7.2 | 0.327 | 0.041 |  |
Effective cost weight * | 14.8 ±13.6 | 13.3 ±11.4 | 17.2 ±14.0 | 14.5 ±13.6 | 19.2±18.5 | 0.623 | 0.256 |  |
 | Average change per year | |||||||
Mean | 95% CI | p | ||||||
ICU stay (days) | 26.0 ± 1.9 | 19.5 ± 2.2 | 18.5 ± 2.3 | 16.3 ± 2.3 | 15.8 ± 2.8 | −2.7 | −4.1 to −1.3 | < 0.001 |
Ventilation (hours) | 571.4 ± 41.5 | 455.0 ± 47.3 | 404.1 ± 49.2 | 362.0 ± 49.9 | 467.9 ± 60.9 | −42.0 | −72.6 to −11.4 | 0.008 |
Antibiotic use (days) | 14.3 ± 1.2 | 12.0 ± 1.3 | 13.8 ± 1.4 | 12.1 ± 1.4 | 9.0 ± 1.7 | −1.0 | −1.9 to −0.2 | 0.02 |
Antibiotic costs (EUR/patient) | 407.6 ± 57.2 | 420.7 ± 66.7 | 426.6 ± 67.7 | 393.2 ± 68.5 | 373.9 ± 83.7 | −14.3 | −55.7 to 27.1 | 0.495 |
ICU reinfection rate (proportion) | 0.31 ± 0.07 | 0.37 ± 0.08 | 0.13 ± 0.06 | 0.12 ± 0.06 | 0.08 ± 0.06 | −35.1% | −53.9% to −8.5% | 0.014 |
28-day mortality (proportion) | 0.54 ± 0.06 | 0.51 ± 0.07 | 0.55 ± 0.08 | 0.48 ± 0.07 | 0.34 ± 0.01 | −22.4% | −44.3% to 8.1% | 0.133 |