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Table 2 Spectrum of clinical presentations of severe malaria in children in Kilifi, Kenya and Mbale, Uganda

From: Endotoxaemia is common in children with Plasmodium falciparummalaria

 

KDH

MRRH

P

Age (months) a

48.5 (37.6-70.7)

24 (13.1-42.3)

<0.0001

Impaired perfusion b

79.2% (38/48)

73.2% (115/157)

0.410

Respiratory distress b

45.8% (22/48)

91.1% (143/157)

<0.0001

Impaired consciousness b

91.7% (44/48)

54.1% (85/157)

<0.0001

Coma b

31.3% (15/48)

14% (22/157)

0.007

Severe anaemia b

14.6% (7/48)

32.9% (50/152)

0.014

Mortality (48 h) b

4.2% (2/48)

5.1% (8/157)

0.794

Endotoxaemia b

12.5% (6/48)

31.2% (49/157)

0.01

High endotoxaemia b

2.1% (1/48)

11.5% (18/157)

0.05

  1. a Shown are median and in parenthesis 25th and 75th percentile. For comparison of difference in age between groups, Kruskal-Wallis H test was used.
  2. b Percentage of children presenting with syndrome and in parenthesis the number of children presenting with a syndrome over the total number of children in that group. For comparison of the proportion of children presenting with a given syndrome, Pearson χ2 was used. Differences in mortality were not calculated because all cases occurred in the group of children with severe malaria and shock.
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BMC Infectious Diseases

ISSN: 1471-2334

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